Treatment beneficial in smoldering multiple myeloma

August 1, 2013
Treatment beneficial in smoldering multiple myeloma
For patients with smoldering multiple myeloma, treatment with lenalidomide plus dexamethasone correlates with delayed progression and improved survival, according to a study published in the Aug. 1 issue of the New England Journal of Medicine.

(HealthDay)—For patients with smoldering multiple myeloma, treatment with lenalidomide plus dexamethasone correlates with delayed progression and improved survival, according to a study published in the Aug. 1 issue of the New England Journal of Medicine.

María-Victoria Mateos, M.D., Ph.D., from the Hospital Universitario de Salamanca in Spain, and colleagues conducted an open-label, phase 3 trial in which 119 patients with high-risk smoldering myeloma were randomized to treatment or observation. Treatment included an induction regimen (nine cycles of plus dexamethasone) followed by maintenance lenalidomide for two years.

After a median follow-up of 40 months, the researchers found that the median time to progression was significantly longer in the treatment group (median not reached) versus the observation group (21 months; hazard ratio for progression, 0.18). The treatment group also had a significantly higher three-year survival rate (94 versus 80 percent; hazard ratio for death, 0.31). In the treatment group, a partial response or better was achieved by 79 percent of patients after the induction phase and by 90 percent during the maintenance phase.

"In conclusion, this randomized, phase 3 trial showed that early treatment with lenalidomide and dexamethasone, followed by maintenance therapy with lenalidomide, in patients with high-risk smoldering multiple myeloma significantly delayed the time to progression to symptomatic disease and resulted in an overall ," the authors write.

The study was funded by Celgene, the manufacturer of lenalidomide.

Explore further: Chemo combination promising for multiple myeloma

More information: Full Text (subscription or payment may be required)

Related Stories

Chemo combination promising for multiple myeloma

May 2, 2012

(HealthDay) -- For patients with relapsed or refractory multiple myeloma, combination treatment with elotuzumab, lenalidomide, and low-dose dexamethasone is generally well tolerated, with encouraging response rates, according ...

Bortezomib ups response, survival in multiple myeloma

July 23, 2012

(HealthDay) -- For patients with newly diagnosed multiple myeloma (MM), induction treatment with a combination of bortezomib, doxorubicin, and dexamethasone (PAD) followed by bortezomib maintenance therapy improves complete ...

New drug improves survival in multiple myeloma relapse

January 24, 2013

Researchers at Moffitt Cancer Center and colleagues have investigated the safety, efficacy and the maximum tolerated dose of pomalidomide for patients with multiple myeloma who have disease relapsed after treatments with ...

Recommended for you

Researchers thwart cancer cells by triggering 'virus alert'

August 27, 2015

Working with human cancer cell lines and mice, researchers at the Johns Hopkins Kimmel Cancer Center and elsewhere have found a way to trigger a type of immune system "virus alert" that may one day boost cancer patients' ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.