Treatment beneficial in smoldering multiple myeloma

Treatment beneficial in smoldering multiple myeloma
For patients with smoldering multiple myeloma, treatment with lenalidomide plus dexamethasone correlates with delayed progression and improved survival, according to a study published in the Aug. 1 issue of the New England Journal of Medicine.

(HealthDay)—For patients with smoldering multiple myeloma, treatment with lenalidomide plus dexamethasone correlates with delayed progression and improved survival, according to a study published in the Aug. 1 issue of the New England Journal of Medicine.

María-Victoria Mateos, M.D., Ph.D., from the Hospital Universitario de Salamanca in Spain, and colleagues conducted an open-label, phase 3 trial in which 119 patients with high-risk smoldering myeloma were randomized to treatment or observation. Treatment included an induction regimen (nine cycles of plus dexamethasone) followed by maintenance lenalidomide for two years.

After a median follow-up of 40 months, the researchers found that the median time to progression was significantly longer in the treatment group (median not reached) versus the observation group (21 months; hazard ratio for progression, 0.18). The treatment group also had a significantly higher three-year survival rate (94 versus 80 percent; hazard ratio for death, 0.31). In the treatment group, a partial response or better was achieved by 79 percent of patients after the induction phase and by 90 percent during the maintenance phase.

"In conclusion, this randomized, phase 3 trial showed that early treatment with lenalidomide and dexamethasone, followed by maintenance therapy with lenalidomide, in patients with high-risk smoldering multiple myeloma significantly delayed the time to progression to symptomatic disease and resulted in an overall ," the authors write.

The study was funded by Celgene, the manufacturer of lenalidomide.

More information: Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Chemo combination promising for multiple myeloma

May 02, 2012

(HealthDay) -- For patients with relapsed or refractory multiple myeloma, combination treatment with elotuzumab, lenalidomide, and low-dose dexamethasone is generally well tolerated, with encouraging response ...

Bortezomib ups response, survival in multiple myeloma

Jul 23, 2012

(HealthDay) -- For patients with newly diagnosed multiple myeloma (MM), induction treatment with a combination of bortezomib, doxorubicin, and dexamethasone (PAD) followed by bortezomib maintenance therapy ...

Multiple myeloma clinical trial closes early

Apr 05, 2007

Mayo Clinic Cancer Center announced today that a multiple myeloma clinical trial has shown a significant improvement in survival with lenalidomide plus low-dose dexamethasone therapy compared to lenalidomide plus high-dose ...

New drug improves survival in multiple myeloma relapse

Jan 24, 2013

Researchers at Moffitt Cancer Center and colleagues have investigated the safety, efficacy and the maximum tolerated dose of pomalidomide for patients with multiple myeloma who have disease relapsed after treatments with ...

Recommended for you

Early hormone therapy may be safe for women's hearts

2 hours ago

(HealthDay)—Healthy women at low risk of cardiovascular disease may be able to take hormone replacement therapy soon after menopause for a short time without harming their hearts, according to a new study.

Low yield for repeat colonoscopy in some patients

3 hours ago

(HealthDay)—Repeat colonoscopies within 10 years are of little benefit to patients who had no polyps found on adequate examination; however, repeat colonoscopies do benefit patients when the baseline examination was compromised, ...

Cell's recycling center implicated in division decisions

5 hours ago

Most cells do not divide unless there is enough oxygen present to support their offspring, but certain cancer cells and other cell types circumvent this rule. Researchers at The Johns Hopkins University have now identified ...

User comments