Functional outcome explored in those at risk for psychosis

September 7, 2013
Functional outcome explored in those at risk for psychosis
Measures of social and role functioning predict functional outcome in those at clinical high risk for psychosis, and poor functional outcome is not entirely dependent on conversion to full-blown disease, according to research published online Sept. 4 in JAMA Psychiatry.

(HealthDay)—Measures of social and role functioning predict functional outcome in those at clinical high risk for psychosis, and poor functional outcome is not entirely dependent on conversion to full-blown disease, according to research published online Sept. 4 in JAMA Psychiatry.

Ricardo E. Carrion, Ph.D., of the Zucker Hillside Hospital in Glen Oaks, N.Y., and colleagues conducted a prospective, naturalistic, longitudinal follow-up study of 100 patients to develop a predictive model of functional outcome in those at clinical high risk for psychosis.

The researchers found that poor social outcome was significantly associated with reduced processing speed (odds ratio [OR], 1.38), impaired social functioning at baseline (OR, 1.85), and total disorganized symptoms (OR, 5.06). Poor role outcome was significantly associated with reduced performance on tests for (OR, 1.74), role functioning at baseline (OR, 1.34), and motor disturbances (OR, 1.77). Among high-risk patients who did not convert to psychosis, 40.3 percent had poor social outcomes and 45.5 percent had poor role outcomes.

"Results from this study support the increasing emphasis on as a critically important outcome that parallels conversion to psychosis and suggest that both psychosis and long-term are equally important targets for prevention," the authors write.

Several study authors disclosed to pharmaceutical companies.

Explore further: Functional MRI can improve prediction of CBT success

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Functional MRI can improve prediction of CBT success

January 4, 2013

(HealthDay)—Results of functional brain imaging can greatly improve prediction of which patients with social anxiety disorder (SAD) will benefit from cognitive behavioral therapy (CBT), according to a study published in ...

Early predictors of disability after spine trauma identified

July 8, 2013

(HealthDay)—The presence of hypotension, hyperglycemia, and moderate or severe traumatic brain injury early after spine trauma are independent predictors of functional disability at one year, according to a review published ...

Recommended for you

Oxytocin enhances spirituality, new study says

September 21, 2016

Oxytocin has been dubbed the "love hormone" for its role promoting social bonding, altruism and more. Now new research from Duke University suggests the hormone may also support spirituality.

Study reveals a biological link between stress and obesity

September 21, 2016

Metabolic and anxiety-related disorders both pose a significant healthcare burden, and are in the spotlight of contemporary research and therapeutic efforts. Although intuitively we assume that these two phenomena overlap, ...

Men with anxiety are more likely to die of cancer, study says

September 20, 2016

Men over 40 who are plagued with the omnipresent of generalized anxiety disorder are more than twice as likely to die of cancer than are men who do not have the mental affliction, new research finds. But for women who suffer ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.