High cholesterol ups MI risk more in men than women

High cholesterol ups MI risk more in men than women
Dyslipidemia seems to be more dangerous for men than women with regard to acute myocardial infarction risk, according to a study published in the September issue of Epidemiology.

(HealthDay)—Dyslipidemia seems to be more dangerous for men than women with regard to acute myocardial infarction (AMI) risk, according to a study published in the September issue of Epidemiology.

Erik Madssen, from the Norwegian University of Science and Technology, and colleagues analyzed data from a prospective, population-based cohort involving 23,525 women and 20,725 men aged younger than 60 years at baseline to examine the differential effect of dyslipidemia by sex. Participants were followed for 12 years for a first AMI.

The researchers found that, in relation to AMI risk, dyslipidemia and male sex enhanced the effect of one another. Among men, the proportion of AMI cases with dyslipidemia that could be attributed to this synergism alone was 0.46 (95 percent confidence interval [CI], 0.35 to 0.57) for high total serum cholesterol, 0.23 (95 percent CI, 0.05 to 0.41) for low high-density lipoprotein (HDL) cholesterol, and 0.52 (95 percent CI, 0.42 to 0.62) for high non-HDL cholesterol. The relative increased risk for AMI due to synergism of elevated total cholesterol and male sex was 3.92. For men and women, obesity and hypertension were similarly detrimental to AMI risk.

"Our results suggest that in middle age, dyslipidemia is much more detrimental for men than for women, and that preventing has a greater potential to reduce the occurrence of AMI among men," the authors write. "In contrast, hypertension and obesity were equally detrimental for women as for men."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Flu vaccination protects patients at risk for acute MI

Aug 22, 2013

(HealthDay)—Recent influenza does not predict acute myocardial infarction (AMI), but vaccination offers a significant protective benefit for the prevention of AMI, according to research published online ...

AMI up with stress-induced hyperglycemia after hip fx

Jul 15, 2013

(HealthDay)—For patients after hip fracture, stress-induced hyperglycemia is associated with an increased risk of acute myocardial infarction (AMI), according to a study published online July 11 in Diabetes Ca ...

Cold weather produces more heart attacks

Sep 01, 2013

Cold weather leads to more heart attacks, according to research presented at ESC Congress 2013 today by professor Marc Claeys from Belgium. The multifactorial study of nearly 16,000 patients found no relationship between ...

Recommended for you

NT-proBNP modestly improves CVD risk prediction in women

15 minutes ago

(HealthDay)—N-terminal pro-B-type natriuretic peptide (NT-proBNP) modestly improves cardiovascular disease (CVD) risk prediction for women, according to a study published in the Oct. 28 issue of the Journal of ...

User comments