Phototherapy affects serum 25(OH)D levels

September 19, 2013
Phototherapy affects serum 25(OH)D levels
For patients with inflammatory skin conditions, phototherapy with ultraviolet (UV) A1 radiation induces a reduction in serum 25-hydroxyvitamin D3 (25[OH]D) levels, whereas narrowband UVB (UVBnb) and UVA/UVBnb induces significant increases in serum 25(OH)D, according to a study published in the October issue of the Journal of the American Academy of Dermatology.

(HealthDay)—For patients with inflammatory skin conditions, phototherapy with ultraviolet (UV) A1 radiation induces a reduction in serum 25-hydroxyvitamin D3 (25[OH]D) levels, whereas narrowband UVB (UVBnb) and UVA/UVBnb induces significant increases in serum 25(OH)D, according to a study published in the October issue of the Journal of the American Academy of Dermatology.

Laurence Feldmeyer, M.D., Ph.D., from University Hospital Zurich, and colleagues examined the influence of UVA1, UVBnb, and UVA/UVBnb phototherapy on of 25(OH)D and related parameters in 116 patients with , psoriasis, morphea, and other inflammatory skin conditions. The participants underwent UVA1 (38 participants), UVA/UVBnb (30 participants), or UVBnb (48 participants) two to three times per week for 53 to 90 days.

The researchers found that, after the therapy, UVBnb phototherapy correlated with a significant increase in serum 25(OH)D, from 22.1 to 39.5 ng/mL. Upon application of UVBnb phototherapy, the increase in 25(OH)D was steeper with a lower baseline 25(OH)D. A significant increase in serum 25(OH)D was also seen with UVA/UVBnb therapy, from 23.9 to 50.3 ng/mL. In contrast, in the UVA1 therapy group there was a significant decrease in 25(OH)D serum levels, from 21.9 to 19.0 ng/mL.

"In conclusion, phototherapy has an impact on 25(OH)D levels in the serum," the authors write. "Our study data [call] for closer examination of a potential confounding effect of various and the need for oral vitamin D supplementation in UVA1-treated patients."

The study was funded by Spirig Pharmaceuticals.

Explore further: Vitamin D deficiency linked to Type 1 diabetes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Vitamin D deficiency linked to Type 1 diabetes

November 15, 2012

A study led by researchers from the University of California, San Diego School of Medicine has found a correlation between vitamin D3 serum levels and subsequent incidence of Type 1 diabetes. The six-year study of blood levels ...

Sunscreen use may lead to vitamin D deficiency

April 27, 2012

(HealthDay) -- Using the amount and sun protection factor (SPF) of sunscreen recommended by the World Health Organization (WHO) is associated with little or no vitamin D production, suggesting that regular sunscreen use may ...

Recommended for you

Zika in fetal brain tissue responds to a popular antibiotic

November 30, 2016

Working in the lab, UC San Francisco researchers have identified fetal brain tissue cells that are targeted by the Zika virus and determined that azithromycin, a common antibiotic regarded as safe for use during pregnancy, ...

Zika and glaucoma linked for first time in new study

November 30, 2016

A team of researchers in Brazil and at the Yale School of Public Health has published the first report demonstrating that the Zika virus can cause glaucoma in infants who were exposed to the virus during gestation.

Flu forecasts successful on neighborhood level

November 30, 2016

Scientists at Columbia University's Mailman School of Public Health developed a computer model to predict the onset, duration, and magnitude of influenza outbreaks for New York City boroughs and neighborhoods. They found ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.