Scientists find promising way to boost body's immune surveillance via p53

September 18, 2013

Researchers at A*STAR's Singapore Immunology Network (SIgN) have discovered a new mechanism involving p53, the famous tumour suppressor, to fight against aggressive cancers. This strategy works by sabotaging the ability of the cancer cells to hide from the immune system. Published in the prestigious Nature Communications journal, this research opens a new avenue to improve targeted cancer therapy by harnessing the body's own immune system to control and eliminate cancer cells.

Also known as the "Guardian of the Genome", p53 fights cancer by causing damaged cells to die or by halting the growth of before they become cancerous and spread to the rest of the body. Ironically, because of its pivotal role in coordinating a range of cancer-fighting mechanisms in the human body, it is also one of the most important cancer-causing genes when mutated. Studies have shown that more than 50% of all human cancers carry defects in the , and almost all other cancers with a normal carry other defects which indirectly impair the cancer-fighting function of p53.

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system. Therefore, having less MHC I molecules may allow cancer cells to hide better and escape detection by the immune system. 

Using two cancer cell lines differing only in the integrity of p53 gene, the scientists observed that cancer cells with defective p53 had much less MHC class I on the cell surface. Specifically, they discovered that p53 moderates the expression of MHC I by controlling the amount of another protein called ERAP1 in the cells. Interestingly, a number of disease conditions including tumour , multiple sclerosis and autoimmune disease were recently reported to be associated with ERAP1.

The team leader, Associate Professor Ren Ee Chee from SIgN said, "We were surprised to discover that p53 regulates MHC class I production by acting through ERAP1. This may explain how cancer cells escape detection by our body's immune system. More importantly, it opens up exciting avenues of research to explore how restoration of p53 with drugs such as those that target ERAP1 can help to harness the immune system to recognise and destroy cancer cells."

Acting Executive Director of SIgN, Associate Professor Laurent Rénia said, "The team has uncovered a new door to manipulate one of the most studied yet enigmatic cancer-associated genes of our times. I am confident that this work will pave the way for more targeted, efficient and cost-effective treatment for the millions of cancer patients globally."

p53 also plays a role in virus infection by increasing MHC I. This is a microscope image of lung infected with H1N1 influenza virus. Upon H1N1 viral infection, the cells showed an increase in MHC class I (green) and p53 (red) expression. The co-expression of increased MHC class I and p53 is in yellow. This demonstrates that p53àERAP1àMHC I pathway also occurs in viral infection. It may be interesting to explore the role of p53 in viral infection.

Explore further: Deficiency in p53 anti-tumor protein delays DNA repair after radiation

More information: www.nature.com/ncomms/2013/130822/ncomms3359/full/ncomms3359.html

Related Stories

Wip1 could be new target for cancer treatment

May 6, 2013

Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new target for the treatment ...

Recommended for you

Team finds early inflammatory response paralyzes T cells

August 18, 2015

In a discovery that is likely to rewrite immunology text books, researchers at UC Davis have found that early exposure to inflammatory cytokines, such as interleukin 2, can "paralyze" CD4 T cells, immune components that help ...

SIV shrugs off antibodies in vaccinated monkeys

August 11, 2015

New research on monkeys vaccinated against HIV's relative SIV calls into question an idea that has driven AIDS vaccine work for years. The assumption: a protective vaccine only needs to stimulate moderate levels of antibodies ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.