New recommendations for standardizing studies of thyroid hormone and disease from ATA taskforce

© Mary Ann Liebert, Inc., publishers

Despite tens of thousands of studies in the literature on the thyroid gland, thyroid hormone, and thyroid disease, lack of standardization in study design makes it difficult to compare the results and apply them to the development of improved diagnostic and treatment approaches. A new report from the American Thyroid Association's Taskforce on Approaches and Strategies to Investigate Thyroid Hormone Economy includes 70 specific recommendations and accompanying commentaries on a range of topics. The report is available free online on the Thyroid website.

Understanding the physiology of the and the activity of thyroid hormone in healthy individuals and in patients with disorders such as hypothyroidism, hyperthyroidism, and is essential for developing new, more effective clinical practice and therapeutic strategies. Much knowledge is gained from studying and in animal and cell models.

Antonio C. Bianco, University of Miami Miller School of Medicine, and Chair of the ATA Taskforce, led a team of specialists in basic thyroid research in a review of the literature to identify which experimental practices would benefit from standardization. The panel of experts then defined consensus recommendations for how best to standardize study design and experimental approaches to achieve more reproducible results, in the "American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models."

"This is an outstanding and comprehensive guide for translational and basic that has filled an important gap in our thyroid research field," says Bryan R. Haugen, MD, President of the ATA and Professor of Medicine and Pathology, Head, Division of Endocrinology, Metabolism & Diabetes, Mary Rossick Kern and Jerome H. Kern Chair in Endocrine Neoplasms Research, University of Colorado School of Medicine. "Dr. Bianco and the entire Taskforce are to be commended for developing this authoritative and extremely useful reference."

"This is a unique compilation of detailed recommendations for performing experiments focusing on the pathophysiology of the thyroid using cell and animal models. It will guide numerous researchers how to best conduct these experiments and will lead to more standardized approaches in many laboratories worldwide," says Peter A. Kopp, MD, Editor-in-Chief of Thyroid and Associate Professor of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, and Interim Director of the Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago.

More information: Thyroid, the peer-reviewed journal from Mary Ann Liebert, Inc., publishers, is the official journal of the American Thyroid Association (ATA).

add to favorites email to friend print save as pdf

Related Stories

Improving voice outcomes after thyroid surgery

Jun 04, 2013

The American Academy of Otolaryngology—Head and Neck Surgery Foundation on Tuesday published a new Clinical Practice Guideline on "Improving Voice Outcomes after Thyroid Surgery" to recognize the importance of the patient's ...

Thyroid problems linked to irregular heart rhythm

Nov 28, 2012

People with an overactive thyroid gland (hyperthyroidism) carry a greater risk of developing irregular heart rhythm (known as atrial fibrillation) than those with normal thyroid function, finds a study published on BMJ today. ...

Thyroid conditions raise risk of pregnancy complications

May 29, 2013

Pregnant women who have thyroid disorders face greater risk of preterm birth and other complications that have short- and long-term consequences for the health of mother and child, according to a recent study accepted for ...

A new type of nerve cell found in the brain

Dec 21, 2012

Scientists at Karolinska Institutet in Sweden, in collaboration with colleagues in Germany and the Netherlands, have identified a previously unknown group of nerve cells in the brain. The nerve cells regulate ...

Recommended for you

New technology that is revealing the science of chewing

17 hours ago

CSIRO's 3D mastication modelling, demonstrated for the first time in Melbourne today, is starting to provide researchers with new understanding of how to reduce salt, sugar and fat in food products, as well ...

After skin cancer, removable model replaces real ear

Apr 11, 2014

(HealthDay)—During his 10-year struggle with basal cell carcinoma, Henry Fiorentini emerged minus his right ear, and minus the hearing that goes with it. The good news: Today, the 56-year-old IT programmer ...

Italy scraps ban on donor-assisted reproduction

Apr 09, 2014

Italy's Constitutional Court on Wednesday struck down a Catholic Church-backed ban against assisted reproduction with sperm or egg donors that has forced thousands of sterile couples to seek help abroad.

Pot growers association launched in Jamaica

Apr 06, 2014

A group of influential Jamaicans gathered Saturday to launch an association of supposed future marijuana cultivators as momentum builds toward loosening laws prohibiting pot on the Caribbean island.

User comments