No serious adverse reactions to HPV vaccination

Researchers at Karolinska Institutet in Sweden and their Danish colleagues have monitored HPV-vaccinated girls via patient data registries in order to examine the incidence of a wide range of diseases and thus determine if there are any serious adverse effects of the vaccine. Their results show no significant increase of the examined diseases in the vaccinated girls relative to their unvaccinated peers.

The study included almost a million Swedish and Danish girls born between 1988 and 2000, and compared roughly 300,000 girls who had been HPV vaccinated with 700,000 who had not. All the girls were between 10 and 17 at time of vaccination, and the vaccines had been administered at some time between 2006 and 2010. The researchers then used patient registries in Denmark and Sweden to study the incidence of any serious of the vaccine.

The researchers examined 53 different diagnoses requiring hospital or specialist care, including blood clots, neurological diseases, and autoimmune diseases such as type 1 diabetes. They found that none of these diseases were more common in the vaccinated group than in the unvaccinated group. Mild adverse effects, such as temporary fever and swelling at the site of injection, were not studied however.

"You could see our study as part of a societal alarm system, and as such it did not alert us to any signs that HPV vaccination carries a risk of serious ," says Dr Lisen Arnheim-Dahlström, associate professor at Karolinska Institutet's Department of Medical Epidemiology and Biostatistics. "We will, of course, be continuing to monitoring HPV vaccination in terms of both this and its efficacy over time."

In Sweden, HPV vaccination has been available through the general vaccination programme to between the ages of 11 and 12 since 2012. Over 120 million doses of the HPV used in Sweden (Gardasil) have been administered around the world. The majority of adverse effects reported to the Swedish Medical Products Agency have included fever, headache, local swelling at the site of injection and other mild reactions. However, as the present study did not consider data from primary care, such mild events do not appear in its results.

More information: "Autoimmune, neurologic, and venous thromboembolic adverse events following administration of a quadrivalent HPV-vaccine to adolescent girls: a cohort study in Denmark and Sweden", Lisen Arnheim-Dahlström, Björn Pasternak, Henrik Svanström, Pär Sparén and Anders Hviid, British Medical Journal, online 9 October 2013.

add to favorites email to friend print save as pdf

Related Stories

1 in 5 boys got HPV shot in first year recommended

Aug 29, 2013

A new report offers a first look at how many boys are getting shots designed to protect girls from cervical cancer. Health officials say the number getting vaccinated so far is a good start.

Recommended for you

New breast cancer imaging method promising

1 hour ago

The new PAMmography method for imaging breast cancer developed by the University of Twente's MIRA research institute and the Medisch Spectrum Twente hospital appears to be a promising new method that could ...

Palliation is rarely a topic in studies on advanced cancer

1 hour ago

End-of-life aspects, the corresponding terminology, and the relevance of palliation in advanced cancer are often not considered in publications on randomized controlled trials (RCTs). This is the result of an analysis by ...

Breast cancer replicates brain development process

1 hour ago

New research led by a scientist at the University of York reveals that a process that forms a key element in the development of the nervous system may also play a pivotal role in the spread of breast cancer.

Is genetic instability the key to beating cancer?

3 hours ago

Cancerous tumors may be poised at the edge of their own destruction, an insight that could help researchers find new, more effective treatments, suggest SFI External Professor Ricard Solé and colleagues in an April 9 paper ...

Phase 3 study may be game-changer for acute myeloid leukemia

7 hours ago

Moffitt Cancer Center researchers say clinical trials for a new experimental drug to treat acute myeloid leukemia (AML) are very promising. Patients treated with CPX-351, a combination of the chemotherapeutic drugs cytarabine ...

User comments