Sparing the body, breast cancer treatment via nipple injection

Sparing the body, breast cancer treatment via nipple injection
This is an example of gene-targeting in a mouse mammary gland using this technique. Here, a fluorescent gene-targeting substance was injected via the nipple duct, and is shown to have targeted an example gene, cyclophilin. Credit: JoVE

On October 4, JoVE, the Journal of Visualized Experiments, will publish a new technique for breast cancer treatment and prevention—injection of therapeutics via the nipple. The procedure, demonstrated on mice, offers direct access to the most common origin of breast cancer, the milk ducts, and could be used to offer cancer therapy that spares healthy regions of the body.

"Local delivery of therapeutic agents into the breast, through intra-nipple injection, could diminish the side effects typically observed with systemic chemotherapy—where the toxic drugs pass through all of the tissues of the body," said Dr. Silva Krause, one of the researchers behind the experiment, "It also prevents drug breakdown by the liver, for example, which can rapidly reduce effective drug levels."

According to Krause, she and her colleagues have already begun experimentation in applying the method. "The authors have utilized this technique to inject a new nanoparticle-based therapeutic that inhibits a specific gene that drives breast cancer formation," said Krause, "This targeted treatment was shown to prevent cancer progression in mice that spontaneously develop mammary tumors, [and] is currently in review in Science Translational Medicine."

This video is not supported by your browser at this time.
In this video, scientists demonstrate how to deliver drugs to the mammary gland via nipple-injection. Credit: JoVE

In order to better communicate their procedure, Krause and her colleagues decided to publish with JoVE. "Because the reader can actually watch the process and see how reagents, instruments, and animals are physically handled over time, the likelihood of reproducing this method in their own labs is greatly enhanced," Krause said. "We believe this will help spread this new technical capability to many labs who are carrying out research."

add to favorites email to friend print save as pdf

Related Stories

Fragile X syndrome protein linked to breast cancer progression

Sep 18, 2013

A research team led by scientists from VIB/KU Leuven, Belgium, and the University of Rome Tor Vergata, Italy, in collaboration with several research centers and hospitals in Italy, the United Kingdom and, Belgium, has identified ...

Alternative target for breast cancer drugs

Jul 19, 2013

Scientists have identified higher levels of a receptor protein found on the surface of human breast tumour cells that may serve as a new drug target for the treatment of breast cancer. The results, which are published today ...

Protein predicts breast cancer prognosis

Aug 29, 2013

Researchers have identified a protein that they believe may help predict breast cancer prognosis, potentially relieving thousands of women at low risk from having to undergo painful, oft-debilitating therapies, while insuring ...

Recommended for you

US women's awareness of breast density varies

7 hours ago

Disparities in the level of awareness and knowledge of breast density exist among U.S. women, according to the results of a Mayo Clinic study published in the Journal of Clinical Oncology.

Study shows why some brain cancers resist treatment

8 hours ago

Scientists at The University of Texas MD Anderson Cancer Center may have discovered why some brain cancer patients develop resistance to standard treatments including radiation and the chemotherapy agent temozolomide.

Researchers identify genes responsible for lung tumors

10 hours ago

The lung transcription factor Nkx2-1 is an important gene regulating lung formation and normal respiratory functions after birth. Alterations in the expression of this transcription factor can lead to diseases such as lung ...

Lycopene may ward off kidney cancer in older women

11 hours ago

A higher intake by postmenopausal women of the natural antioxidant lycopene, found in foods like tomatoes, watermelon and papaya, may lower the risk of renal cell carcinoma, a type of kidney cancer.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.