Exhaled breath biomarker may detect lung cancer

Researchers at Cleveland Clinic recently discovered that lung cancer may be detected in patients by testing their exhaled breath. Preliminary studies suggest that an accurate exhaled breath biomarker could be developed for use as a clinical test. Findings were presented at CHEST 2013 in Chicago, Illinois.

"We believe that cancer cells release a unique chemical signature related to the tumor-growing process," said Peter J. Mazzone, MD, FCCP, director of the lung cancer program for the Respiratory Institute at Cleveland Clinic. "We are currently developing a breath-based test based on the results of our research."

Dr. Mazzone and his colleagues studied 82 people with biopsy-confirmed lung cancer who had not yet received treatment against a control group of 155 people who were either at-risk for lung cancer or who had benign lung nodules. Subjects were asked to breathe normally while their breath was exposed to a high-dimensional chemical sensor called a colorimetric sensor array. The colors on the array change when exposed to various chemicals. If the chemicals in the breath contained markers for lung cancer, the array would show that in a pattern of color changes. The colorimetric sensor array continually monitored the chemicals exhaled from the breath of the subjects, resulting in sensor changes that accurately distinguished the breath of people with from the controls.

"Lung cancer is the leading cause of cancer death in the United States," said Michael H. Baumann, MD, MS, FCCP, president-elect, ACCP. "We welcome the cutting-edge research that can help in diagnosis and treatment of this devastating illness."

add to favorites email to friend print save as pdf

Related Stories

Trial seeks to sniff out lung cancer

Jun 19, 2012

Cancer smells different. Past research has shown that dogs can detect lung cancer in a person’s breath with great accuracy. But dogs are  tricky to use as a diagnostic tool; what does it mean when a dog barks once ...

New device uses gold nanoparticles to test for lung cancer

Nov 17, 2011

The metabolism of lung cancer patients is different than the metabolism of healthy people. And so the molecules that make up cancer patients' exhaled breath are different too. A new device pioneered at the University of Colorado ...

Recommended for you

Endogenous hormones improve breast cancer risk models

17 hours ago

(HealthDay)—Inclusion of endogenous hormones in prediction models improves prediction of invasive breast cancer risk in postmenopausal women, according to a study published online Aug. 18 in the Journal of ...

Novel oncogenic RET mutation found in small cell lung cancer

18 hours ago

For the first time an oncogenic somatic mutation at amino acid 918 in the RET (rearranged during transfection) protein has been identified in small cell lung cancer (SCLC) tumors and enforced expression of this mutation within ...

User comments