High-dose rhBMP linked to increased incidence of cancer

High-dose rhBMP linked to increased incidence of cancer

(HealthDay)—Patients receiving high-dose recombinant human bone morphogenetic protein-2 (rhBMP-2) as part of spine surgery have an increased risk of cancer and may be at risk for major complications, according to two studies published in the Sept. 4 issue of The Journal of Bone & Joint Surgery.

In an effort to examine the risk of new cancers in patients receiving high-dose rhBMP-2, Eugene J. Carragee, M.D., from the Stanford University School of Medicine in Redwood City, Calif., and colleagues used data from a multicenter trial involving patients with degenerative lumbar spine conditions who underwent single-level instrumented posterolateral arthrodesis with high-dose rhBMP-2 in a compression-resistant matrix (rhBMP-2/CRM; 239 patients) or autogenous bone graft (control; 224 patients). The researchers found that the incidence rate of new cancer events was 3.37 per 100 person-years in the rhBMP-2/CRM group versus 0.50 in the control group (incidence rate ratio, 6.75 at two years). At five years, the incidence of cancer events was still significantly greater in the rhBMP-2/CRM group.

Addisu Mesfin, M.D., from the University of Rochester in New York, and colleagues examined the short- and long-term outcomes and medical and linked to high-dose rhBMP-2 in a cohort of 502 patients who received high-dose rhBMP-2 as part of spinal surgery. The researchers found that the rates of intraoperative complications, perioperative major surgical complications, and perioperative major were 8.2, 11.6, and 11.6 percent, respectively. No significant association was found for rhBMP-2 with radiculopathy, seroma, or .

"Major surgical complications occurred in 11.6 percent of , and 11.6 percent experienced major medical complications," Mesfin and colleagues write.

One or more authors from both studies, or their institutions, disclosed a financial tie with an entity in the biomedical arena.

More information: Abstract - Carragee
Full Text (subscription or payment may be required)
Abstract - Mesfin
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Major complications predicted by age, back surgery type

Sep 20, 2013

(HealthDay)—American Society of Anesthesiologists (ASA) class, age, and type of back surgery are independent risk factors for major medical complications, according to research published in the Sept. 1 ...

Recommended for you

Females ignored in basic medical research

Aug 28, 2014

A new study from Northwestern Medicine has found that surgical researchers rarely use female animals or female cells in their published studies—despite a huge body of evidence showing that sex differences can play a crucial ...

Technology to eliminate fungus from surgical materials

Aug 28, 2014

Specialists in Mexico have developed a system that combines antifungal properties of different materials. This scientific product destroys microorganisms that proliferate in the living systems and confers ...

User comments