Researcher finds a new role for the benefits of oxygen

In a study published in published in EMBO Molecular Medicine, a Dartmouth researcher found that dying heart cells are kept alive with spikes of oxygen.

During a attack when the flow of -rich blood to a section of the heart is interrupted, and not quickly restored, heart muscle begins dying. Deprived of oxygen and other essential nutrients, cell death continues occurring over a period of time leading to progressive loss of heart function and .

Current therapies are not effective at limiting cell loss—they only slow down the progression of congestive heart failure.

Periannan Kuppusamy, PhD, professor of radiology at Geisel School of Medicine at Dartmouth, found that dying still contain enough oxygen for metabolism, and additional short-term spikes of oxygen keep the cells alive and active.

His research team used an animal model of and discovered that daily administration of a higher concentration of oxygen for a short period of time each day induced spikes in myocardial oxygenation, which prevented myocardial injury.

"We all know that oxygen is crucial for survival, but it is intriguing to know that the same oxygen can be used like a drug to treat disease," Kuppusamy says.

Curious about the molecular mechanism of oxygen in treating myocardial injury, he began examining the effect of oxygen on p53, a transcription factor that regulates cell cycle and triggers programmed . To his surprise he saw the 'oxygen spikes' altering the function of p53 from a death-inducing protein, to promoting transcription of genes that help dying cardiac cells survive.

Kuppusamy sees a link between the results of the present study to the age-old practice of breathing exercises for human well-being. He says, "Controlled breathing can increase tissue oxygenation, and if practiced on a daily basis, can lead to suppression of disease progression."

His research at Dartmouth also focusses on the effect of oxygen in cancer therapy.

More information: onlinelibrary.wiley.com/doi/10… m.201202055/abstract

add to favorites email to friend print save as pdf

Related Stories

A coordinated response to cardiac stress

Mar 01, 2013

Myocardial hypertrophy, a thickening of the heart muscle, is an adaptation that occurs with increased stress on the heart, such as high blood pressure. As the heart muscle expands, it also requires greater blood flow to maintain ...

Atmospheric oxygenation three billion years ago

Sep 25, 2013

Oxygen appeared in the atmosphere up to 700 million years earlier than we previously thought, according to research published today in the journal Nature, raising new questions about the evolution of ear ...

Recommended for you

Neutralising antibodies for safer organ transplants

17 hours ago

Serious complications can arise following kidney transplants. If dialysis is required within the first seven days, then the transplanted organ is said to have a Delayed Graft Function (DGF), and essentially ...

User comments