Researchers track lethal prostate cancer to determine clonal origin

Prostate cancer has variable manifestations, ranging from relatively benign localized tumors to widespread life-threatening metastases. The origin of most prostate cancer metastases can be traced back to the primary tumor; therefore, understanding the mutations in the primary tumor that promote cancer spread is of great interest.

In this issue of the Journal of Clinical Investigation, Srinivasan Yegnasubramanian and colleagues at Johns Hopkins University track the development of lethal in a patient. Using tissue samples taken throughout the progression of the cancer, the authors identified the origin of the lethal clone. Surprisingly, in this case the lethal clone originated from a small, low-grade foci in the and not from the larger high-grade region of the tumor.

In the accompanying commentary, Rose Brannon and Charles Sawyers of Memorial Sloan-Kettering Cancer Center discuss the importance of individual case studies and how a comprehensive database of such studies is needed to identify common patterns in .

More information: Tracking the clonal origin of lethal prostate cancer, J Clin Invest. DOI: 10.1172/JCI70354
"N of 1" case reports in the era of whole-genome sequencing, J Clin Invest. 2013;123(11):4568–4570. DOI: 10.1172/JCI70935

add to favorites email to friend print save as pdf

Related Stories

Mayo Clinic genomic analysis lends insight to prostate cancer

May 23, 2013

Mayo Clinic researchers have used next generation genomic analysis to determine that some of the more aggressive prostate cancer tumors have similar genetic origins, which may help in predicting cancer progression. The findings ...

Recommended for you

Unraveling the 'black ribbon' around lung cancer

Apr 17, 2014

It's not uncommon these days to find a colored ribbon representing a disease. A pink ribbon is well known to signify breast cancer. But what color ribbon does one think of with lung cancer?

User comments