Researchers track lethal prostate cancer to determine clonal origin

Prostate cancer has variable manifestations, ranging from relatively benign localized tumors to widespread life-threatening metastases. The origin of most prostate cancer metastases can be traced back to the primary tumor; therefore, understanding the mutations in the primary tumor that promote cancer spread is of great interest.

In this issue of the Journal of Clinical Investigation, Srinivasan Yegnasubramanian and colleagues at Johns Hopkins University track the development of lethal in a patient. Using tissue samples taken throughout the progression of the cancer, the authors identified the origin of the lethal clone. Surprisingly, in this case the lethal clone originated from a small, low-grade foci in the and not from the larger high-grade region of the tumor.

In the accompanying commentary, Rose Brannon and Charles Sawyers of Memorial Sloan-Kettering Cancer Center discuss the importance of individual case studies and how a comprehensive database of such studies is needed to identify common patterns in .

More information: Tracking the clonal origin of lethal prostate cancer, J Clin Invest. DOI: 10.1172/JCI70354
"N of 1" case reports in the era of whole-genome sequencing, J Clin Invest. 2013;123(11):4568–4570. DOI: 10.1172/JCI70935

Related Stories

Mayo Clinic genomic analysis lends insight to prostate cancer

date May 23, 2013

Mayo Clinic researchers have used next generation genomic analysis to determine that some of the more aggressive prostate cancer tumors have similar genetic origins, which may help in predicting cancer progression. The findings ...

Recommended for you

Old cancer drug could have new use in fighting cancer

date 1 hour ago

A drug used for decades to treat leukemia may have other uses in the fight against cancer, researchers at the University of Missouri have found. Previously, doctors used 6-Thioguanine, or 6-TG, as a chemotherapy ...

Cancer prevention efforts in the US a mixed bag

date 14 hours ago

While there has been substantial progress in some cancer control efforts in the past several decades, like reductions in smoking and increased utilization of cancer screening, progress in some areas is lagging, according ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.