Stopping transplant drugs before conception benefits fetus

Research suggests that fetal exposure to mycophenolic acid products (MPA)—which are drugs taken by transplant recipients to prevent rejection—may increase the risk of birth defects and spontaneous abortions. Results of this study will be presented at ASN Kidney Week 2013 November 5-10 at the Georgia World Congress Center in Atlanta, GA.

To investigate these potential links, Serban Constantinescu, MD, PhD (Temple University School of Medicine) and his colleagues analyzed data from the National Transplantation Pregnancy Registry (NTPR), comparing 163 female who discontinued MPA prior to conception with 114 recipients who conceived while taking MPA.

In recipients who discontinued MPA, there were more live births (79% vs. 43%), a lower incidence of miscarriages (19% vs. 52%), and a lower incidence of (6% vs. 14%). Kidney problems during and after pregnancy were similar in the two groups of transplant recipients.

"The results of this study generate multiple questions. Continued close collaboration among specialists will help to better identify potential pregnancy risks in kidney transplant recipients, particularly as new immunosuppressive agents are developed," said Dr. Constantinescu. "Individual physicians and transplant centers are encouraged to report all pregnancy exposures in transplant recipients to the National Transplantation Pregnancy Registry, which was designed specifically to assess the safety of pregnancy in solid organ ."

More information: "Pregnancy Outcomes in Kidney Recipients Who Discontinued Mycophenolic Acid Products Prior to Conception." (Abstract 3136)

Related Stories

Successful pregnancy possible after kidney transplant

date Oct 20, 2011

A new study recently published in the American Journal of Transplantation reveals that the ability to successfully carry a pregnancy after kidney transplantation is very high, with 73.5% live birth rates.

Recommended for you

AMA: avoiding distress in medical school

date May 22, 2015

(HealthDay)—Understanding the key drivers underlying medical students' distress can help address the issues and enhance student well-being, according to an article published by the American Medical Association.

European court to rule on right-to-die case

date May 21, 2015

Europe's human rights court will on June 5 rule on whether a man in a vegetative state can be taken off life support, a case that has ignited a fierce euthanasia debate in France, a spokesman said Thursday.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.