Study uncovers potential to alleviate tissue damage during strokes or transplant

October 29, 2013 by Helen Dodson
Study uncovers potential to alleviate tissue damage during strokes or transplant
Credit: Shutterstock

A new study from Yale School of Medicine uncovers clues as to how a key part of the immune system is regulated to avoid tissue injury to human organs after stroke or transplant. The study, in the journal Developmental Cell, focuses on a type of white blood cell called a neutrophil, and how regulation of the granules inside can protect organs such as kidneys from injury.

The research team uncovered a previously unknown role of a protein complex of STK24 and CCM3 in regulating the release of granules from neutrophils. The complex acted in a way that prevented the release of too many , which would acerbate damage.

Senior author Dianqing Wu, professor of pharmacology, explains the implications of the study for stroke patients and those who have undergone tissue transplants. "This study provides potential new therapeutic targets to alleviate during strokes and tissue transplantation," he said.

Wu added, "This study, by revealing the basic cellular function of CCM3, also points a new direction for the investigation of the pathogenic basis for Cerebral Cavernous Malformation (CCM) disease." CCM is a life-threatening neurovascular disease, which can be caused by mutations in CCM3. 

Explore further: Peritoneal dialysis as an intervention for stroke patients

More information: www.cell.com/developmental-cell/abstract/S1534-5807(13)00569-8

Related Stories

Peritoneal dialysis as an intervention for stroke patients

September 3, 2013

Ischemic stroke is characterized by an interruption of the blood supply to the brain, which can lead to brain damage and even death. Excess amounts of the excitatory neurotransmitter glutamate are released during stroke events ...

A surprise mechanism uncovered in the development of lupus

October 25, 2012

In a study with a surprising outcome, scientists at Yale School of Medicine have discovered that an enzyme complex known for promoting natural resistance to bacteria and fungi unexpectedly inhibits the development of lupus. ...

Recommended for you

Gut microbe movements regulate host circadian rhythms

December 1, 2016

Even gut microbes have a routine. Like clockwork, they start their day in one part of the intestinal lining, move a few micrometers to the left, maybe the right, and then return to their original position. New research in ...

Reactivation of embryonic genes leads to muscle aging

December 1, 2016

Developmental genes and pathways strictly regulate embryogenesis. The process is strongly driven by so-called Hox-genes. Now, researchers from the Leibniz Institute on Aging (FLI) in Jena, Germany, can show that one of these ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.