Study uncovers potential to alleviate tissue damage during strokes or transplant

by Helen Dodson
Study uncovers potential to alleviate tissue damage during strokes or transplant
Credit: Shutterstock

A new study from Yale School of Medicine uncovers clues as to how a key part of the immune system is regulated to avoid tissue injury to human organs after stroke or transplant. The study, in the journal Developmental Cell, focuses on a type of white blood cell called a neutrophil, and how regulation of the granules inside can protect organs such as kidneys from injury.

The research team uncovered a previously unknown role of a protein complex of STK24 and CCM3 in regulating the release of granules from neutrophils. The complex acted in a way that prevented the release of too many , which would acerbate damage.

Senior author Dianqing Wu, professor of pharmacology, explains the implications of the study for stroke patients and those who have undergone tissue transplants. "This study provides potential new therapeutic targets to alleviate during strokes and tissue transplantation," he said.

Wu added, "This study, by revealing the basic cellular function of CCM3, also points a new direction for the investigation of the pathogenic basis for Cerebral Cavernous Malformation (CCM) disease." CCM is a life-threatening neurovascular disease, which can be caused by mutations in CCM3. 

More information: www.cell.com/developmental-cel… 1534-5807(13)00569-8

Related Stories

Peritoneal dialysis as an intervention for stroke patients

date Sep 03, 2013

Ischemic stroke is characterized by an interruption of the blood supply to the brain, which can lead to brain damage and even death. Excess amounts of the excitatory neurotransmitter glutamate are released during stroke events ...

A surprise mechanism uncovered in the development of lupus

date Oct 25, 2012

In a study with a surprising outcome, scientists at Yale School of Medicine have discovered that an enzyme complex known for promoting natural resistance to bacteria and fungi unexpectedly inhibits the development ...

Stem cell clues uncovered

date Jul 12, 2013

Proper tissue function and regeneration is supported by stem cells, which reside in so-called niches. New work from Carnegie's Yixian Zheng and Haiyang Chen identifies an important component for regulating stem cell niches, ...

Recommended for you

Researchers reveal a genetic blueprint for cartilage

date Jul 02, 2015

Cartilage does a lot more than determine the shapes of people's ears and noses. It also enables people to breathe and to form healthy bones—two processes essential to life. In a study published in Cell Re ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.