Study examines amyloid deposition in patients with traumatic brain injury

November 11, 2013

Patients with traumatic brain injury (TBI) had increased deposits of β-Amyloid (Aβ) plaques, a hallmark of Alzheimer Disease (AD), in some areas of their brains in a study by Young T. Hong, Ph.D., of the University of Cambridge, England, and colleagues.

There may be epidemiological or pathophysiological (changes because of injury) links between TBI and AD, and Aβ plaques are found in as many as 30 percent of patients who die in the acute phase after a TBI. The plaques appear within hours of the injury and can occur in patients of all ages, according to the study background.

Researchers used imaging and brain tissue acquired during autopsies to examine Aβ deposition in patients with TBI. Researchers performed (PET) imaging using carbon 11-labeled Pittsburgh Compound B ([ 11 C]PIB), a marker of brain amyloid deposition, in 15 participants with a TBI and 11 healthy patients. Autopsy-acquired was obtained from 16 people who had a TBI, as well as seven patients with a nonneurological cause of death.

The study's findings indicate that patients with TBI showed increases in [ 11 C]PIB binding, which may be a marker of Aβ plaque in some areas of the .

"The use of ([ 11 C]PIB PET for amyloid imaging following TBI provides us with the potential for understanding the pathophysiology of TBI, for characterizing the mechanistic drivers of disease progression or suboptimal recovery in the subacute phase of TBI, for identifying at high risk of accelerated AD, and for evaluating the potential of antiamyloid therapies," the authors conclude.

More information: JAMA Neurol. Published online November 11, 2013. DOI: 10.1001/.jamaneurol.2013.4847

Related Stories

Have a brain injury? You may be at higher risk for stroke

June 26, 2013

People who have a traumatic brain injury (TBI) may be more likely to have a future stroke, according to research that appears in the June 26, 2013, online issue of Neurology, the medical journal of the American Academy of ...

Can traumatic brain injury impair a child's working memory?

September 26, 2013

Traumatic brain injury (TBI) during childhood can have long-term effects on cognitive and psychosocial functioning, including poor academic achievement. Pediatric TBI can cause significant deficits in working memory, as demonstrated ...

Alzheimer's collaboration brings time-course to equation

October 3, 2013

Scientists from Western Australia and across the nation have shown the accumulation of a protein in the brain occurs 20 years before symptoms of Alzheimer's occur, in a groundbreaking study that could prove beneficial for ...

Recommended for you

Research grasps how the brain plans gripping motion

July 28, 2015

With the results of a new study, neuroscientists have a firmer grasp on the way the brain formulates commands for the hand to grip an object. The advance could lead to improvements in future brain-computer interfaces that ...

New research rethinks how we grab and hold onto objects

July 28, 2015

It's been a long day. You open your fridge and grab a nice, cold beer. A pretty simple task, right? Wrong. While you're debating between an IPA and a lager, your nervous system is calculating a complex problem: how hard to ...

It don't mean a thing if the brain ain't got that swing

July 27, 2015

Like Duke Ellington's 1931 jazz standard, the human brain improvises while its rhythm section keeps up a steady beat. But when it comes to taking on intellectually challenging tasks, groups of neurons tune in to one another ...

Sleep makes our memories more accessible, study shows

July 27, 2015

Sleeping not only protects memories from being forgotten, it also makes them easier to access, according to new research from the University of Exeter and the Basque Centre for Cognition, Brain and Language. The findings ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.