Study examines amyloid deposition in patients with traumatic brain injury

Patients with traumatic brain injury (TBI) had increased deposits of β-Amyloid (Aβ) plaques, a hallmark of Alzheimer Disease (AD), in some areas of their brains in a study by Young T. Hong, Ph.D., of the University of Cambridge, England, and colleagues.

There may be epidemiological or pathophysiological (changes because of injury) links between TBI and AD, and Aβ plaques are found in as many as 30 percent of patients who die in the acute phase after a TBI. The plaques appear within hours of the injury and can occur in patients of all ages, according to the study background.

Researchers used imaging and brain tissue acquired during autopsies to examine Aβ deposition in patients with TBI. Researchers performed (PET) imaging using carbon 11-labeled Pittsburgh Compound B ([ 11 C]PIB), a marker of brain amyloid deposition, in 15 participants with a TBI and 11 healthy patients. Autopsy-acquired was obtained from 16 people who had a TBI, as well as seven patients with a nonneurological cause of death.

The study's findings indicate that patients with TBI showed increases in [ 11 C]PIB binding, which may be a marker of Aβ plaque in some areas of the .

"The use of ([ 11 C]PIB PET for amyloid imaging following TBI provides us with the potential for understanding the pathophysiology of TBI, for characterizing the mechanistic drivers of disease progression or suboptimal recovery in the subacute phase of TBI, for identifying at high risk of accelerated AD, and for evaluating the potential of antiamyloid therapies," the authors conclude.

More information: JAMA Neurol. Published online November 11, 2013. DOI: 10.1001/.jamaneurol.2013.4847

add to favorites email to friend print save as pdf

Related Stories

Have a brain injury? You may be at higher risk for stroke

Jun 26, 2013

People who have a traumatic brain injury (TBI) may be more likely to have a future stroke, according to research that appears in the June 26, 2013, online issue of Neurology, the medical journal of the American Academy of Neu ...

Recommended for you

Link seen between seizures and migraines in the brain

1 hour ago

Seizures and migraines have always been considered separate physiological events in the brain, but now a team of engineers and neuroscientists looking at the brain from a physics viewpoint discovered a link ...

Neuroscience: Why scratching makes you itch more

7 hours ago

Turns out your mom was right: Scratching an itch only makes it worse. New research from scientists at Washington University School of Medicine in St. Louis indicates that scratching causes the brain to release ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.