Etanercept cuts sciatic pain from lumbar disc herniation

Etanercept cuts sciatic pain from lumbar disc herniation

(HealthDay)—Compared with placebo, transforaminal injections of etanercept provide relief from leg and back pain in patients with symptomatic lumbar disc herniation (LDH), according to research published in the Nov. 1 issue of Spine.

Brian J.C. Freeman, D.M., of the University of Adelaide in Australia, and colleagues randomized 49 patients, aged 18 to 70 years, who had persistent lumbosacral radicular pain secondary to LDH, to receive (0.5 mg, 2.5 mg, or 12.5 mg) or placebo as two transforaminal epidural injections, two weeks apart.

The researchers found that mean daily worst leg pain was significantly reduced in patients receiving 0.5-mg etanercept compared with those receiving placebo. Among these patients, 50 percent reported a 100 percent reduction in worst at four weeks compared with none of the patients receiving placebo. No difference was observed in the incidence of adverse events in the etanercept and groups.

"Epidural etanercept may offer with sciatica a safe and effective nonoperative treatment," the authors write.

Two study authors are employed by BioAssets Development Corporation (now a wholly-owned subsidiary of Teva Pharmaceuticals), which funded the study.

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Charles_Weber
not rated yet Dec 20, 2013
Aneurysms, herniated discs, hemorrhoids, high cholesterol, and emphysema are among the most destructive, painful, and numerous diseases in our society. Slipped or herniated discs are estimated to cost 200 billion dollars directly and indirectly each year in the USA alone [http://www.future...8.4.1.51 ]. Four to six of 100 Americans autopsied died of a ruptured aneurysm. 3.6 to 6 percent of those examined had non ruptured brain aneurysms [Renkel]. Each year, 16,000 Americans die due to a ruptured aortic aneurysm. Of the 200,000 strokes that occur each year in the USA, 20% are aneurysms in the brain. I suspect that copper deficiency status is the most important parameter affecting them. For instance, aneurysms are produced in turkeys by depleting copper [Guenther]. Copper deficiency causes blood vessels to become weak and is probably the chief cause of hemorrhoids and varicose veins. Restoring copper during those diseases is imperative.