Etanercept cuts sciatic pain from lumbar disc herniation

Etanercept cuts sciatic pain from lumbar disc herniation

(HealthDay)—Compared with placebo, transforaminal injections of etanercept provide relief from leg and back pain in patients with symptomatic lumbar disc herniation (LDH), according to research published in the Nov. 1 issue of Spine.

Brian J.C. Freeman, D.M., of the University of Adelaide in Australia, and colleagues randomized 49 patients, aged 18 to 70 years, who had persistent lumbosacral radicular pain secondary to LDH, to receive (0.5 mg, 2.5 mg, or 12.5 mg) or placebo as two transforaminal epidural injections, two weeks apart.

The researchers found that mean daily worst leg pain was significantly reduced in patients receiving 0.5-mg etanercept compared with those receiving placebo. Among these patients, 50 percent reported a 100 percent reduction in worst at four weeks compared with none of the patients receiving placebo. No difference was observed in the incidence of adverse events in the etanercept and groups.

"Epidural etanercept may offer with sciatica a safe and effective nonoperative treatment," the authors write.

Two study authors are employed by BioAssets Development Corporation (now a wholly-owned subsidiary of Teva Pharmaceuticals), which funded the study.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Phentermine, topiramate reduce progression to T2DM

Oct 21, 2013

(HealthDay)—Over two years, phentermine and topiramate extended-release (PHEN/TPM ER) treatment plus lifestyle changes lead to significant weight loss and a considerable reduction in progression to type ...

Recommended for you

Female baby boomers with asthma? You may need help

1 hour ago

Women over the age of 65 face numerous barriers to good health: an increased risk for obesity, greater struggles against poverty and higher rates of asthma with worse health outcomes. An article published in the August issue ...

New guidelines help keep asthma out of 'yellow zone'

1 hour ago

If you have asthma, you may have an asthma action plan with a "stoplight system" to help you recognize and respond to changes and understand when symptoms are getting worse and need more attention. If you're in the green ...

User comments

Adjust slider to filter visible comments by rank

Display comments: newest first

Charles_Weber
not rated yet Dec 20, 2013
Aneurysms, herniated discs, hemorrhoids, high cholesterol, and emphysema are among the most destructive, painful, and numerous diseases in our society. Slipped or herniated discs are estimated to cost 200 billion dollars directly and indirectly each year in the USA alone [http://www.future...8.4.1.51 ]. Four to six of 100 Americans autopsied died of a ruptured aneurysm. 3.6 to 6 percent of those examined had non ruptured brain aneurysms [Renkel]. Each year, 16,000 Americans die due to a ruptured aortic aneurysm. Of the 200,000 strokes that occur each year in the USA, 20% are aneurysms in the brain. I suspect that copper deficiency status is the most important parameter affecting them. For instance, aneurysms are produced in turkeys by depleting copper [Guenther]. Copper deficiency causes blood vessels to become weak and is probably the chief cause of hemorrhoids and varicose veins. Restoring copper during those diseases is imperative.