Hybrid heart valve is strong, durable in early tests

November 18, 2013

A hybrid heart valve created from thin and highly elastic mesh embedded within layers of human cells was strong and durable in a study presented at the American Heart Association's Scientific Sessions 2013.

Researchers created a three-dimensional cell culture by coating a scaffold of nickel-titanium alloy (Nitinol), used for devices that require flexibility and motion, with layers of smooth muscle, and lining cells. The valves performed well in a heart simulator, opening and closing under various pressures and remaining stable and strong throughout the tests.

A durable, regenerating hybrid heart valve would be an important advance because previous attempts to create tissue-engineered heart valves from patients' cells have been unsatisfactory. All the prior methods entail significant limitations due to structural vulnerability, short-term functionality and mechanical properties of the tissue-engineered valves.

Explore further: Researchers creating next generation prosthetic heart valves

Related Stories

Researchers creating next generation prosthetic heart valves

September 18, 2013

Researchers in the School of Biomedical Engineering and the Department of Mechanical Engineering at Colorado State University are working on developing replacement heart valves that will be superior to current mechanical ...

Recommended for you

Gut microbes signal to the brain when they are full

November 24, 2015

Don't have room for dessert? The bacteria in your gut may be telling you something. Twenty minutes after a meal, gut microbes produce proteins that can suppress food intake in animals, reports a study published November 24 ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.