More mastectomy, less radiation in male breast CA management

November 20, 2013
More mastectomy, less radiation in male breast CA management

(HealthDay)—Surgical management of male breast cancer (MBC) is considerably different from that of female breast cancer (FBC), according to a study published in the Nov. 15 issue of the International Journal of Radiation Oncology, Biology, Physics.

Emma C. Fields, M.D., from the University of Colorado School of Medicine in Aurora, and colleagues utilized data from the Surveillance, Epidemiology, and End Results database to identify all primary invasive breast cancer, male or female, diagnosed from 1973 to 2008.

The researchers found that there were 4,276 cases of MBC (0.6 percent of all cases) and 718,587 cases of FBC. Mastectomy was used in 87.4 percent of MBC cases versus 38.3 percent of FBC, and breast-conserving surgery was used in 12.6 and 52.6 percent, respectively (P < 10−4). For males with localized , there was no significant difference in cause-specific survival (CSS) for the 4.6 percent treated with lumpectomy/radiation therapy (RT) versus the 70 percent treated with mastectomy alone (hazard ratio, 1.33; P = 0.57). For men with regional cancer, post-mastectomy RT was delivered in 33 percent of cases and was not associated with an improvement in CSS (hazard ratio, 1.11; P = 0.37). Use of post-mastectomy RT in MBC increased significantly over time. CSS for MBC improved over time, with the largest significant change for men diagnosed in 1998 to 2008 versus 1973 to 1987.

"Surgical management of MBC is dramatically different than for FBC," the authors conclude.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Young breast cancer patients often opt for mastectomy

May 30, 2013

A new study of young women with breast cancer has found that most chose to have a mastectomy rather than a surgical procedure that would conserve the breast, researchers will report at the 49th Annual Meeting of the American ...

Recommended for you

New treatment options for a fatal leukemia

July 27, 2015

In industrialized countries like in Europe, acute lymphoblastic leukemia is the most common form of cancer in children. An international research consortium lead by pediatric oncologists from the Universities of Zurich and ...

Exciting results from cancer immunoagent study

July 20, 2015

(Medical Xpress)—Cancer therapies have improved incrementally over the years, but cancer treatment largely remains analogous to forest fire suppression, in which the spread of fire is contained with deliberate controlled ...

Modified DNA building blocks are cancer's Achilles heel

July 22, 2015

In studying how cells recycle the building blocks of DNA, Ludwig Cancer Research scientists have discovered a potential therapeutic strategy for cancer. They found that normal cells have highly selective mechanisms to ensure ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.