Rotavirus vaccination may also protect children against seizures

A new study suggests an additional—and somewhat surprising—potential benefit of vaccinating children against rotavirus, a common cause of diarrhea and vomiting. Besides protecting kids from intestinal illness caused by rotavirus, immunization may also reduce the risk of related seizures, according to findings published in Clinical Infectious Diseases and available online.

Lead study author Daniel C. Payne, PhD, MSPH, from the Centers for Disease Control and Prevention (CDC), and colleagues from CDC and other institutions carried out a retrospective analysis that included roughly a quarter of a million U.S. children born between March 2006 and November 2009. All were enrolled in the Vaccine Safety Datalink, a nationwide project that collects data for vaccine safety research, and included 186,502 children fully immunized against rotavirus (74.4 percent) and 64,099 who were not (25.6 percent).

The researchers found that children who were fully vaccinated against rotavirus had an approximately 20 percent reduced risk of seizure-related hospitalizations and emergency department visits during the year following vaccination, compared to unvaccinated children. "The protective association we found between rotavirus vaccination and is another good reason for having your child fully vaccinated against rotavirus," Dr. Payne said.

Although several mechanisms could explain the protective association, the most probable, the study authors wrote, is that "vaccination directly prevents systemic , including extra-intestinal complications involving the central nervous system." Seizures have been observed in children with acute intestinal illness caused by rotavirus: A large multi-center Canadian study from 2007, for example, estimated that 7 percent of young patients hospitalized with rotavirus illness experienced seizures.

The authors of this latest study estimated that rotavirus vaccination could potentially save more than $7 million in U.S. health care costs each year by preventing approximately 1,000 hospitalizations and 5,000 for seizures among young children. "Caring for who have seizures can be expensive and emotionally taxing for families," Dr. Payne said. "Seizures sometimes lead to painful procedures, medication regimens, trips to the emergency room, or hospital stays."

The reduction in seizure risk the researchers found complements the already well-documented benefits of vaccinating kids against rotavirus—declines in doctor's office visits, visits, and hospitalizations for severe diarrhea—noted Geoffrey A. Weinberg, MD, of the University of Rochester School of Medicine and Dentistry, in an accompanying editorial.

"Work such as this not only is interesting scientifically, but provides yet another reason to strongly promote universal immunization," Dr. Weinberg wrote. "In addition, the work provides us an opportunity to reflect on the fact that sometimes, unexpected effects of vaccination are beneficial and are a cause for celebration, rather than the more commonly publicized concern for unexpected adverse effects."

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Volunteer guidelines for clinicians in the Ebola epidemic

7 minutes ago

Disaster Medicine and Public Health Preparedness Journal has released a novel, informative article that speaks to volunteers within the Ebola epidemic. The article, contributed by a consortium of Boston-based hospitals, is ent ...

US lawmaker: New case raises questions on Ebola

1 hour ago

The new case of Ebola diagnosed in New York City has raised "even more questions about procedures in treating patients and risks to Americans," a Republican committee chairman said Friday.

Aid group: Ebola contagion risk can't be zero

1 hour ago

Despite stringent infection-control measures, the risk of Ebola's spread cannot be entirely eliminated, Doctors Without Borders said Friday after one of its doctors caught the dreaded disease while working in Guinea and went ...

WHO eyes mass Ebola vaccines by mid-2015

1 hour ago

Hundreds of thousands of Ebola vaccine doses could be rolled out to west Africa by the middle of next year, the World Health Organization said Friday, after new cases of the killer virus were reported in New York and Mali.

User comments