Biomarker identified in systemic sclerosis predicts progression

Biomarker identified in systemic sclerosis predicts progression

(HealthDay)—Patients with systemic sclerosis have elevated levels of CXCL4, which predicts disease risk and progression, according to a study published online Dec. 18 in the New England Journal of Medicine.

Lenny van Bon, M.D., from the Boston University School of Medicine, and colleagues performed proteome-wide analysis using isolated from healthy individuals and from patients with systemic sclerosis with distinct clinical phenotypes. The findings were validated in five large cohorts of patients with systemic sclerosis, and were compared with those for patients with systemic lupus erythematosus, ankylosing spondylitis, and hepatic fibrosis.

The researchers found that, in systemic sclerosis, the predominant protein secreted by plasmacytoid dendritic cells in circulation and in skin was CXCL4, with a mean level of 25,624 pg/mL, which was significantly higher than that found in controls (92.5 pg/mL) or in patients with (1,346 pg/mL), ankylosing spondylitis (1,368 pg/mL), or liver fibrosis (1,668 pg/mL). There was a correlation between CXCL4 levels and skin and lung fibrosis and pulmonary arterial hypertension. Of the chemokines, only CXCL4 predicted systemic sclerosis risk and progression. CXCL4 induced inflammatory cell influx and skin transcriptome changes in vivo.

"Levels of CXCL4 were elevated in patients with and correlated with the presence and progression of complications, such as lung fibrosis and ," the authors write.

More information: Full Text

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Fatigue, fear are daily lot of Ebola fighters: experts

10 hours ago

Doctors, nurses and hospital workers fighting the Ebola epidemic in west Africa are struggling with a daily burden of exhaustion, shortage of staff and fear for themselves over the deadly virus, specialists say.

Hong Kong makes Ebola 'contingency' measures

13 hours ago

Hong Kong said Wednesday it was quarantining all people from Guinea, Sierra Leone and Liberia who were showing Ebola-like symptoms on arrival in the city, as fears grow worldwide about the spread of the deadly virus.

User comments