Stripped mobile phone camera turned into a mini-microscope for low-cost diagnostics

The test sample is placed directly on the exposed surface of the image sensor chip after removal of the optics.The resolution of such mini-microscopes is dependent on the pixel size of the sensor, but sufficient for identification of several pathogenic parasites. Credit: Johan Lundin Lab / Photographer: Heli Vilmi

Microscopy, being relatively easy to perform at low cost, is the universal diagnostic method for detection of most globally important parasitic infections. Methods developed in well-equipped laboratories are, however, difficult to maintain at the basic levels of the health care system due to lack of adequately trained personnel and resources.

Researchers at the Institute for Molecular Medicine Finland, FIMM, University of Helsinki and Karolinska Institutet, Sweden, have now shown that novel techniques for high-resolution imaging and image transfer over data networks may be utilized to solve these diagnostic problems.

The team led by Dr. Johan Lundin and Dr. Ewert Linder modified inexpensive imaging devices, such as a webcam selling for ten euros and a mobile phone camera, into a mini-microscope. The test sample was placed directly on the exposed surface of the image sensor chip after removal of the optics.

The resolution of such mini-microscopes was dependent on the pixel size of the sensor, but sufficient for identification of several pathogenic parasites.

In their study published in PLOS Neglected Tropical Diseases the researchers were able to use the mini-microscopes they constructed to yield images of parasitic worm eggs present in urine and stools of infected individuals. They first utilized this novel approach to detect urinary schistosomiasis, a severely under diagnosed infection affecting hundreds of millions, primarily in sub-Saharan Africa. For diagnostics at the point-of-care they developed a highly specific pattern recognition algorithm that analyses the image from the mini-microscope and automatically detects the parasite eggs.

"The results can be exploited for constructing simple imaging devices for low-cost diagnostics of urogenital schistosomiasis and other neglected tropical infectious diseases", says Dr. Lundin. "With the proliferation of mobile phones, data transfer networks and digital microscopy applications the stage is set for alternatives to conventional microscopy in endemic areas."

add to favorites email to friend print save as pdf

Related Stories

High-resolution microscopy without a lens

Sep 05, 2012

(Phys.org)—Over the past several years, major advances have been made at UCLA in the field of lens-less computational imaging technology, particularly in the design of lens-free holographic microscopes, which, because of ...

Pushing microscopy beyond standard limits

Jul 29, 2013

Engineers at the California Institute of Technology (Caltech) have devised a method to convert a relatively inexpensive conventional microscope into a billion-pixel imaging system that significantly outperforms ...

Scientists used iPhone to diagnose intestinal worms

Mar 12, 2013

Scientists used an iPhone and a camera lens to diagnose intestinal worms in rural Tanzania, a breakthrough that could help doctors treat patients infected with the parasites, a study said on Tuesday.

Recommended for you

WHO: Number of Ebola cases passes 10,000

1 hour ago

The number of people believed sickened by Ebola has passed 10,000, according to figures released Saturday by the World Health Organization, as the outbreak continues to spread.

NY and NJ say they will require Ebola quarantines

13 hours ago

The governors of New Jersey and New York on Friday ordered a mandatory, 21-day quarantine for all doctors and other arriving travelers who have had contact with Ebola victims in West Africa.

User comments