Added prostate CA criteria may help ID surveillance candidates

Added prostate CA criteria may help ID surveillance candidates

(HealthDay)—Additional predictors, such as prostate-specific antigen (PSA) density and extent of cancer on biopsy, help guide selection of prostate cancer patients for active surveillance programs, according to research published in the February issue of The Journal of Urology.

In an effort to identify predictors of adverse pathology, Annelies Vellekoop, M.D., of New York University in New York City, and colleagues analyzed data for 4,500 men who underwent for Gleason 6 . The researchers included a subset with extended biopsy data.

The researchers found that, based on the inclusion criteria of six currently published protocols, 33 to 45 percent of men with clinically localized Gleason 6 prostate cancer had adverse pathology at radical prostatectomy. Predictors of upgrading and up staging among patients with Gleason 6 prostate cancer included older age, higher levels of PSA, PSA density greater than 0.15 ng/ml/cm³, palpable disease, and extent of cancer greater than 4 mm on biopsy. Larger prostate volume was inversely related to adverse pathology.

"More than a third of men meeting the most stringent active surveillance criteria had adverse pathology at radical prostatectomy in this population-based cohort," the authors write. "Active surveillance programs should consider PSA density and extent of cancer on biopsy for patient selection."

One author disclosed financial ties to Sanofi.

More information: Abstract
Full Text

Related Stories

Implications of very low risk prostate cancer assessed

date Sep 20, 2013

(HealthDay)—The risk of adverse findings at surgery for men with very low risk (VLR) prostate cancer is significantly lower than for those with low risk (LR), according to research published in the October ...

Physical symptoms from prostate biopsy can cause anxiety

date Oct 23, 2013

(HealthDay)—Problematic symptoms of prostate biopsy can lead to increased anxiety in men, even when the biopsy results are negative for cancer, according to research published online Oct. 21 in the Journal of ...

Recommended for you

To stop cancer: Block its messages

date 1 hour ago

The average living cell needs communication skills: It must transmit a constant stream of messages quickly and efficiently from its outer walls to the inner nucleus, where most of the day-to-day decisions ...

Researchers develop new potential drug for rare leukemia

date 2 hours ago

Researchers at the University of Michigan Comprehensive Cancer Center have developed a new drug that shows potential in laboratory studies against a rare type of acute leukemia. And additional studies suggest ...

How immune cells facilitate the spread of breast cancer

date 2 hours ago

The body's immune system fights disease, infections and even cancer, acting like foot soldiers to protect against invaders and dissenters. But it turns out the immune system has traitors amongst their ranks. ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.