Engineered anti-toxin antibodies improve efficacy

The effectiveness of toxin-neutralizing antibodies is considered to be mediated through the interaction of the variable region of the antibody and the toxin; however, recent studies suggest that the constant region (Fc) of antibodies also influence efficacy.

In this issue of the Journal of Clinical Investigation, Jeffrey Ravetch and colleagues at The Rockefeller University demonstrate that engineering the Fc domain of anti-toxin antibodies increases toxin neutralization activity through enhancing the interaction between toxin-targeting antibodies and the Fc receptor on . The authors found that mice expressing humanized FcR were better protected from anthrax toxin when given engineered anti-anthrax toxin antibodies.

This study suggests that engineering the Fc domains of antibodies can be used as a strategy to enhance antibody efficacy.

More information: Human IgG Fc domain engineering enhances antitoxin neutralizing antibody activity, J Clin Invest. DOI: 10.1172/JCI72676

add to favorites email to friend print save as pdf

Related Stories

Liver tropism is key for B cell deletion immunotherapy

Nov 01, 2013

Antibodies against the B cell surface protein CD20 have been used successfully to treat B cell-mediated autoimmune diseases and lymphomas. Antibody binding receptors, called Fc receptors, on other immune cells bind anti-CD20 ...

(Antibody) orientation matters

Dec 10, 2012

The orientation of antibody binding to bacteria can mean life or death to the bug, according to a study published in The Journal of Experimental Medicine on December 10th. These findings may help explain why these bacter ...

Scientists describe how anthrax toxins cause illness, death

Aug 28, 2013

Researchers at the National Institute of Allergy and Infectious Diseases (NIAID) and the National Heart, Lung, and Blood Institute, both part of the National Institutes of Health, have identified the cells in two distinct ...

Antibody builders

Nov 19, 2013

Antibodies are often the first line of defense against the body's invaders.  Built to recognize and attack foreign bacteria and viruses, antibody molecules are released by cells to do battle with microbial ...

Recommended for you

Could trophoblasts be the immune cells of pregnancy?

Dec 18, 2014

Trophoblasts, cells that form an outer layer around a fertilized egg and develop into the major part of the placenta, have now been shown to respond to inflammatory danger signals, researchers from Norwegian University of ...

Moms of food-allergic kids need dietician's support

Dec 18, 2014

Discovering your child has a severe food allergy can be a terrible shock. Even more stressful can be determining what foods your child can and cannot eat, and constructing a new diet which might eliminate entire categories ...

Multiple allergic reactions traced to single protein

Dec 17, 2014

Johns Hopkins and University of Alberta researchers have identified a single protein as the root of painful and dangerous allergic reactions to a range of medications and other substances. If a new drug can ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.