Stimulant, antipsychotic combo improves aggressive behavior

(HealthDay)—For children with attention deficit/hyperactivity disorder (ADHD) and aggressive disorders, the addition of risperidone to a combination of parent training and psychostimulant is associated with moderate improvement in aggressive and disruptive behaviors, according to a study published in the January issue of the Journal of the American Academy of Child & Adolescent Psychiatry.

Michael G. Aman, Ph.D., from The Ohio State University in Columbus, and colleagues randomized 168 children aged 6 to 12 years old with ADHD and oppositional-defiant disorder (124 children) or conduct disorder (44 children) with severe physical aggression to a nine-week trial of , stimulant, and either placebo (basic treatment; 84 participants) or (augmented treatment; 84 participants). For three weeks, parents received training and their children received the psychostimulant, titrated for optimal effect, with the placebo or risperidone added if there was room for improvement.

The researchers found that, compared with basic treatment, there were significant improvements on the Nisonger Child Behavior Rating Form Disruptive-Total subscale (P = 0.0016), the Nisonger Child Behavior Rating Form Social Competence subscale (P = 0.0049), and the Antisocial Behavior Scale Reactive Aggression subscale (P = 0.01) with augmented treatment. Both groups showed substantial improvements in the Clinical Global Impressions scores with no difference between the treatments.

"Risperidone provided moderate but variable improvement in aggressive and other seriously disruptive child behaviors when added to parent training and optimized stimulant treatment," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

More information: Abstract
Full Text
Editorial

add to favorites email to friend print save as pdf

Related Stories

Study shows two drugs help adolescents with ADHD, aggression

Dec 20, 2013

Prescribing both a stimulant and an antipsychotic drug to children with physical aggression and attention-deficit/hyperactivity disorder (ADHD), along with teaching parents to use behavior management techniques, reduces aggressive ...

CDC: More than one in 10 kids diagnosed with ADHD

Nov 26, 2013

(HealthDay)—More than one in 10 children and adolescents are diagnosed with attention-deficit/hyperactivity disorder (ADHD), an increase of 42 percent in less than a decade, according to a study published ...

Group training improves parenting skills, child behavior

Nov 08, 2013

(HealthDay)—Group training delivered to parents of toddlers in pediatric office settings improves parenting skills and reduces child disruptive behaviors, according to research published online Nov. 4 in JAMA Pediatrics.

Recommended for you

"Body recognition" compares with fingerprint ID

12 hours ago

(Medical Xpress)—University of Adelaide forensic anatomy researchers are making advances in the use of "body recognition" for criminal and missing persons cases, to help with identification when a face ...

User comments

Adjust slider to filter visible comments by rank

Display comments: newest first

addboymike
not rated yet Jan 26, 2014
Nice to see a study like this. However, This particular meds. combination is nothing new. I can recall being aware of it at least 10-15 years ago.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.