'Beige' cells key to healthy fat

by Richard Saltus
The first two images show subcutaneous fat from mice that were exposed to cold. The fat was “browned” by beige fat cells containing PRDM16. Credit: Paul Cohen

"Beige fat" cells found in healthy subcutaneous fat in mice play a critical role in protecting the body from the disease risks of obesity, report researchers at Dana-Farber Cancer Institute, who say their study findings may have implications for therapy of obesity-related illness in humans.

A report in the journal Cell suggests that the presence of , a type of fat cell that can burn energy to release heat, is what makes subcutaneous obesity relatively healthy compared with inside the abdomen, which largely lacks beige and is associated with increased risks of diabetes, heart disease, and death.

Excess calories in are stored in fatty tissues mainly composed of cells. Beige fat is present in scattered deposits in adult humans, mixed in with white fat. Beige cells can activate a "thermogenic" mechanism that burns stored fat to make heat. When this occurs within white fat, the process is called "browning."

Bruce Spiegelman and Paul Cohen of the Harvard-affiliated Dana-Farber Cancer Institute led the study.

"The findings indicate that PRDM16 and beige adipocytes [fat cells] are required for the 'browning' of white fat and the healthful effects of ," noted the authors. In the future, the discovery "might lead to pharmacologic strategies to treat obesity-related diseases," said Cohen, the study's first author and an instructor of medicine at Harvard Medical School (HMS). "The goal would be to create healthier fat"—possibly by manipulating PRDM16 in the body, he said.

In the second set of slides, the mice exposed to cold did not have browning of their subcutaneous fat due to the of lack of PRDM16. Credit: Paul Cohen

Spiegelman's research group has been at the forefront of discoveries in the past 20 years about how different types of fat cells emit chemical signals that influence body metabolism, in some instances promoting health and in others disrupting metabolism, leading to diseases such as diabetes, hypertension, fatty liver, and heart disease. "Fat cells are the central signaling system to measure how much energy is in your body and what the body needs to do about it," explained Spiegelman, the Stanley J. Korsmeyer Professor of Cell Biology and Medicine at HMS.

Cohen, a cardiologist and postdoctoral fellow in the Spiegelman lab, was interested in the function of beige fat in a physiological context as well as the well-known observation that overweight people whose extra pounds are deposited mainly as visceral fat inside the abdomen and around the liver and other organs have increased risks of high blood pressure, diabetes, and . People who carry extra weight subcutaneously under the skin of the hips and thighs (a pear-shaped pattern) are largely spared these added risks.

The answers to this discrepancy in the health effects of subcutaneous vs. visceral fat have been elusive. Cohen said previous research had found that subcutaneous fat was more prone to browning, while visceral fat cells were marked by inflammation and invasion by immune cells. An aim of the new study was to look for differences in gene expression between subcutaneous and visceral fat cells.

Spiegelman and others have proposed that increasing the amount or the activity of beige fat in people might be useful in treating diseases related to being overweight and obese. Skeptics have argued that beige fat is of minor importance in the overall metabolism of the body.

The new research suggests otherwise, demonstrating that beige cells "make an important contribution to the whole body physiology of mice," noted the authors.

"Identification of pharmacological activators of PRDM16 targeted to beige adipocytes could hold promise as a new class of therapeutics," they suggested.

More information: "What We Talk About When We Talk About Fat." Evan D. Rosen, Bruce M. Spiegelman. Cell - 16 January 2014 (Vol. 156, Issue 1, pp. 20-44). DOI: 10.1016/j.cell.2013.12.012

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