Genetic factors conferring diabetes don't affect progression

January 17, 2014
Genetic factors conferring diabetes don't affect progression

(HealthDay)—Genetic variants that predispose to diabetes are not associated with the rate of progression from diabetes to requirement of insulin treatment, according to a study published online Nov. 1 in Diabetes Care.

Kaixin Zhou, Ph.D., from the University of Dundee in the United Kingdom, and colleagues examined comprehensive for 5,250 patients with type 2 diabetes. The authors sought to identify the association between clinical, biochemical, and with the risk of progression of type 2 diabetes from diagnosis to requirement for .

The researchers found that both low and high body mass index (BMI) were associated with the risk of progression. There were independent associations for faster progression with younger age at diagnosis, higher log triacylglyceride concentrations (hazard ratio, 1.28 per mmol/L), and lower high-density lipoprotein concentrations (hazard ratio, 0.70 per mmol/L), in an analysis stratified by BMI and glycated hemoglobin. Utilizing a genetic risk score derived from 61 diabetes risk variants, a higher score was associated with a younger age of diagnosis and a younger age at starting insulin, but was not associated with the rate of progression.

"The genetic factors that predispose to diabetes are different from those that cause rapid progression of diabetes suggesting a difference in biological process that needs further investigation," the authors write.

Explore further: Genetic risk score linked to increased risk of diabetes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Genetic risk score linked to increased risk of diabetes

July 30, 2013

(HealthDay)—A genetic risk score based on 46 gene variants linked to type 2 diabetes is associated with increases in the risk of type 2 diabetes and declines in glucose control and beta-cell function, according to a study ...

Diabetic peripheral neuropathy prevalent in youth with T2DM

November 8, 2013

(HealthDay)—The prevalence of diabetic peripheral neuropathy (DPN) is 25.7 percent among youth with type 2 diabetes, and is significantly higher than that seen among youth with type 1 diabetes, according to a study published ...

Conventional versus intensive T1DM tx not tied to menopause

January 9, 2014

(HealthDay)—For women with type 1 diabetes, intensive versus conventional treatment is not associated with menopause risk, although greater insulin dose is associated with lower natural menopause risk, according to research ...

Recommended for you

New study reveals a novel protein linked to type 2 diabetes

August 16, 2016

Findings from Boston University School of Medicine (BUSM), which appear in eLife, provide a possible explanation as to why most people who are obese develop insulin resistance and type 2 diabetes. A minority of obese individuals, ...

Gene variant explains differences in diabetes drug response

August 9, 2016

The first results from a large international study of patients taking metformin, the world's most commonly used type 2 diabetes drug, reveal genetic differences among patients that may explain why some respond much better ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.