Melanoma risk up in IBD independent of biologic therapy

Melanoma risk up in IBD independent of biologic therapy

(HealthDay)—Inflammatory bowel disease (IBD) is associated with an increased risk of melanoma, independent of the use of biologic therapy, according to research published in the February issue of Clinical Gastroenterology and Hepatology.

Siddharth Singh, M.B.B.S., of the Mayo Clinic in Rochester, Minn., and colleagues conducted a of the literature and performed a meta-analysis of 12 cohort studies, involving a total of 172,837 with IBD, to assess the association between IBD and risk of .

The researchers found that IBD was associated with an increased risk of melanoma (12 studies: relative risk [RR], 1.37; 95 percent confidence interval [CI], 1.10 to 1.70). The risk of melanoma was increased in patients with Crohn's disease (seven studies: RR, 1.80; 95 percent CI, 1.17 to 2.75) and patients with ulcerative colitis (seven studies: RR, 1.23; 95 percent CI, 1.01 to 1.50). The risk of melanoma was higher in patients with IBD for studies performed prior to 1998, before biologic therapies were introduced (eight studies: RR, 1.52; 95 percent CI, 1.02 to 2.25), but not for studies performed after 1998 (two studies: RR, 1.08; 95 percent CI, 0.59 to 1.96).

"Based on a meta-analysis, IBD has been associated with an increased risk of melanoma, independent of the use of biologic therapy," the authors write. "Patients diagnosed with IBD should be counseled on their risk for melanoma."

More information: Abstract
Full Text
Editorial

add to favorites email to friend print save as pdf

Related Stories

Inflammatory bowel disease raises risk of melanoma

May 20, 2013

Patients with inflammatory bowel disease (IBD) are at higher risk of melanoma, a form of skin cancer, report researchers at Mayo Clinic. Researchers found that IBD is associated with a 37 percent greater risk for the disease. ...

Stage III/IV melanoma patients at risk for new primaries

Dec 10, 2013

(HealthDay)—Patients with stage III or IV melanoma who have not received treatment with BRAF inhibitors remain at risk for developing new primary melanomas (NPMs), although the incidence rates are lower ...

Cancer risk up in bilateral retinoblastoma survivors

Feb 23, 2012

(HealthDay) -- For survivors of bilateral retinoblastoma (Rb), family history is associated with an increased risk of second cancers (SCs), especially melanoma, according to a study published online Feb. 21 ...

Recommended for you

Migraine may double risk for facial paralysis

26 minutes ago

Migraine headache may double the risk of a nervous system condition that causes facial paralysis, called Bell's palsy, according to a new study published in the December 17, 2014, online issue of Neurology, the medical journa ...

Anti-diabetic drug springs new hope for tuberculosis patients

7 hours ago

A more effective treatment for tuberculosis (TB) could soon be available as scientists have discovered that Metformin (MET), a drug for treating diabetes, can also be used to boost the efficacy of TB medication without inducing ...

Chikungunya virus shuts down infected cells

8 hours ago

Researchers from Wageningen University, part of Wageningen UR, in collaboration with colleagues from Leiden University and a research team in Australia, have revealed how chikungunya virus blocks essential ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.