Researchers report new method to detect key indicator of heart diseases

January 16, 2014

A team that includes Dartmouth College researchers has discovered a new way to detect cardiolipin, a key indicator of heart diseases and some genetic disorders.

The results, which appear in the journal Analytical Chemistry, may eventually help to diagnose these conditions earlier on and to provide real-time monitoring of cardiolipin levels.

Cardiolipin is a unique lipid of mitochondria, the cell structures that generate energy. Cardiolipin is important for in both respiration and apoptosis (programmed cell death). This lipid is an important indicator for cardiac diseases, Barth syndrome and Tangier disease and has been linked to neurodegenerative diseases, HIV and cancers.

Scientific interest in cardiolipin has grown dramatically in the recent years because of the critical role of this lipid in apoptosis and its potential in medical diagnosis. But routine cardiolipin analysis has had to rely on 10-nonyl acridine orange (NAO), the only dye available for cardiolipin detection. The dye, however, has many drawbacks in terms of selectivity and sensitivity.

In their new study, researchers report a new fluorescent compound, TTAPE-Me, that acts as a turn-on sensor for cardiolipin, helping to detect it and determine its amount more effectively than NAO.

Explore further: Novel drug acts in unique way to protect against kidney injury

Related Stories

Recommended for you

Are vegetarian diets heart-healthier?

October 18, 2016

(HealthDay)—Vegetarians are assumed to be healthier than carnivores, but a new study questions that assumption. It found meat eaters had no significantly greater risk of heart disease over 10 years compared to those who ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.