Researchers create online colorectal cancer risk calculator

January 3, 2014

January 3, 2014, Cleveland: Researchers at Cleveland Clinic have developed a new tool called CRC-PRO that allows physicians to quickly and accurately predict an individual's risk of colorectal cancer, as published in the current edition of the Journal of the American Board of Family Medicine.

CRC-PRO, or Colorectal Cancer Predicted Risk Online, is designed to help both patients and physicians determine when screening for colorectal cancer is appropriate. Current guidelines recommend patients are screened at the age of 50. However, with this new tool, physicians will be better able to identify who is truly at risk and when screenings for patients are necessary.

To develop the calculator, the researchers – led by Brian Wells, M.D., Ph.D., of the Department of Quantitative Health Sciences in Cleveland Clinic's Lerner Research Institute – analyzed data on over 180,000 patients from a longitudinal study conducted at the University of Hawaii. Patients were followed for up to 11.5 years to determine which factors were highly associated with the development of colorectal cancer.

"Creating a risk calculator that includes multiple risk factors offers clinicians a means to more accurately predict risk than the simple age-based cutoffs currently used in clinical practice," said Dr. Wells. "Clinicians could decide to screen high-risk patients earlier than age 50, while delaying or foregoing screening in low-risk individuals. "

Wells and his colleagues hope that their new, user-friendly calculator will help improve the efficiency of screenings. They also believe prediction tools like this can help lower healthcare costs by cutting down on unnecessary testing.

The Multiethnic Cohort Study comprised a diverse ethnic population. Previously, most research in this area has been performed predominately in Caucasians. Because cancer risk differs drastically in different racial groups, the researchers felt that an ethnically diverse population would more accurately reflect true risk.

"The development of risk prediction calculators like the CRC-PRO is vital for improving medical decision-making," said Michael Kattan, Ph.D., Chair of the Department of Quantitative Health Sciences in Cleveland Clinic's Lerner Research Institute. "Tools like this represent another step toward personalized medicine that will ultimately improve efficiency, outcomes and patient care."

Kattan and his research team are involved in the creation of numerous risk prediction tools, including heart disease and cancers of the breast, prostate and thyroid, that are available at http://rcalc.ccf.org. He is currently working on software that will integrate these tools for automatic calculation in the Electronic Health Record to make this process easier for physicians.

Related Stories

Gut microbes may be a risk factor for colorectal cancer

December 6, 2013

In one of the largest epidemiological studies of human gut bacteria and colorectal cancer ever conducted, a team of researchers at NYU Langone Medical Center has found a clear association between gut bacteria and colorectal ...

Recommended for you

Study reveals new insight into DNA repair

August 3, 2015

DNA double-strand breaks (DSBs) are the worst possible form of genetic malfunction that can cause cancer and resistance to therapy. New information published this week reveals more about why this occurs and how these breaks ...

Strange circular DNA may offer new way to detect cancers

July 30, 2015

Strange rings of DNA that exist outside chromosomes are distinct to the cell types that mistakenly produced them, researchers have discovered. The finding raises the tantalizing possibility that the rings could be used as ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.