Overweight linked with reduced lung function in children with a history of early childhood wheezing

Overweight and obesity are significant risk factors for reduced lung function in school-aged children with a history of early childhood wheezing, according to a study carried out at the University of Eastern Finland. The results also showed that the use of inhaled corticosteroids for asthma in childhood may result in reduced bone mineral density in early teenage years.

"In the light of these results, weight control is especially important for children who have suffered from bronchiolitis in early childhood. As to the use of , particular attention should be paid to using the lowest sufficient dose to maintain adequate control," says Ms Virpi Sidoroff, MD, who presented the results in her doctoral dissertation.

Growing evidence shows that overweight children face increased asthma risk. The link between asthma, allergy, , and obesity in children is unclear. Paediatric use of inhaled corticosteroids (ICS) for asthma has steadily increased. However, knowledge of their long-term safety to bone health remains insufficient.

Between 1991 and 1992, 100 children aged 1–23 months and hospitalised for wheezing were recruited to an early-intervention bronchiolitis study. An additional 14 children were later included in the study group. At the age of four, seven, and 12 years, the participants were invited to follow-up visits consisting of medical examinations, weight and height measurements, skin prick tests for common allergens, and exercise challenge tests to show bronchial hyperreactivity. At the age of twelve years, (BMD) was measured by dual-energy x-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT). The history of ICS use was collected from medical records. Out of the 100 recruited participants, 82 took part in the follow-up visits. 89 out of 114 children attended the bone study.

At 12 years of age, 38% of the participants were asthmatic and 33% were overweight, 20% being obese. The current overweight was associated with a decreased FEV1/FVC ratio at both 7 and 12 years of age and reduced flows in small airways at 12 years. In conclusion, were significant risk factors for reduced lung function at school age in this asthma risk group. However, the study did not reveal a connection between asthma and overweight.

Using ICS for asthma may reduce bone mineral density

During follow-up, 73 of the children received ICS medication. The mean cumulative ICS dose was 517 mg, varying from 31 to 1,813 mg. The cumulative ICS dose was associated with reduced bone mineral density measured by DXA in the femoral neck, and with a lower total bone, cortical, and trabecular bone mineral density documented by pQCT in the radius. The lumbar spine BMD and the apparent volumetric BMD of femoral neck were reduced when ICS were used regularly before 6 years of age. The results indicate that the use of ICS during childhood may reduce density measured during early teenage years.

Ms Sidoroff points out that despite these findings, asthma should never be left untreated. "The aim should be to use the lowest effective dosage of ICS, increasing the dosage only temporarily if symptoms get worse."

More information: epublications.uef.fi/pub/urn_i… 78-952-61-1313-5.pdf

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Gut bacteria promote obesity in mice

Sep 30, 2014

A species of gut bacteria called Clostridium ramosum, coupled with a high-fat diet, may cause animals to gain weight. The work is published this week in mBio, the online open-access journal of the American Society for Microbiol ...

An apple a day could keep obesity away

Sep 29, 2014

Scientists at Washington State University have concluded that nondigestible compounds in apples – specifically, Granny Smith apples – may help prevent disorders associated with obesity. The study, thought ...

Boosting purchasing power to lower obesity rates

Sep 25, 2014

In January, as one of the first major initiatives of the Academic Vision, the Rudd Center for Food Policy and Obesity will move to UConn from Yale University. The move will allow Rudd faculty to expand their work and build ...

Note to young men: Fat doesn't pay

Sep 23, 2014

Men who are already obese as teenagers could grow up to earn up to 18 percent less than their peers of normal weight. So says Petter Lundborg of Lund University, Paul Nystedt of Jönköping University and ...

Waistlines of US adults continue to increase

Sep 16, 2014

The prevalence of abdominal obesity and average waist circumference increased among U.S. adults from 1999 to 2012, according to a study in the September 17 issue of JAMA.

User comments