How can vaccination be improved to eradicate avian influenza H5N1 in Indonesia?

January 13, 2014 by Jh (Annet) Blanken
How can vaccination be improved to eradicate avian influenza H5N1 in Indonesia?

To answer this question, Okti Nadia Poetri researched the effect of vaccination to stop the spread of avian influenza in Indonesia. On January 21 Poetri will defence her thesis of this research.Highly pathogenic avian influenza (HPAI) also known as 'bird flu', is considered to be a major threat to both poultry farming and to public health. In Thailand and in Europe HPAI H5N1 is eradicated, mainly because of stamping out and practicing stringent biosafety measures. When HPAI H5N1 occurred in Indonesia in 2004 farmers were not prepared to adhere to stamping out among others because of the lack of a compensation regime, causing the virus to spread further. Not only poultry is frequently infected with avian influenza in Indonesia, so far no other country has had as many cases of human infections with bird flu.

The current way to control in Indonesia is by the vaccination of poultry kept in large commercial poultry farms. Poetri studied vaccination effectiveness as well as the cause of outbreaks of avian influenza in populations of vaccinated chickens.

Poetri describes how by performing serology in the laboratory test it can be predicted whether a specific vaccine strain can offer protection against a circulating virus. This would in turn reduce animal experiments necessary to assess vaccine efficacy. Her research may eventually contribute to an improvement of the current vaccination strategy.

Guus Koch, PhD, CVI, supported Poetri as co-supervisor in her research. Ivo Claassen, PhD, CVI, worked several years in Indonesia supporting the Indonesian-Netherlands Partnership on the Prevention and Control of Highly Avian Influenza and met Poetri who got involved in the research on effectiveness of the vaccination for HPAI H5N1.

Explore further: FDA approves H5N1 avian influenza vaccine

Related Stories

FDA approves H5N1 avian influenza vaccine

November 26, 2013

(HealthDay)—The U.S. Food and Drug Administration has approved the first adjuvanted vaccine for the prevention of H5N1 influenza in adults at greater-than-average risk of exposure.

Culling more effective than vaccinating

August 8, 2011

In economic and epidemiological terms, the practice of culling on farms within a radius of 1 to 3 km of infected farms is the best method of combating Highly Pathogenic Avian Influenza (HPAI). Vaccinating chickens within ...

Recommended for you

Zika virus infection alters human and viral RNA

October 20, 2016

Researchers at University of California San Diego School of Medicine have discovered that Zika virus infection leads to modifications of both viral and human genetic material. These modifications—chemical tags known as ...

Food-poisoning bacteria may be behind Crohn's disease

October 19, 2016

People who retain a particular bacterium in their gut after a bout of food poisoning may be at an increased risk of developing Crohn's disease later in life, according to a new study led by researchers at McMaster University.

Neurodevelopmental model of Zika may provide rapid answers

October 19, 2016

A newly published study from researchers working in collaboration with the Regenerative Bioscience Center at the University of Georgia demonstrates fetal death and brain damage in early chick embryos similar to microcephaly—a ...

Scientists uncover new facets of Zika-related birth defects

October 17, 2016

In a study that could one day help eliminate the tragic birth defects caused by Zika virus, scientists from the Florida campus of The Scripps Research Institute (TSRI) have elucidated how the virus attacks the brains of newborns, ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.