Smoking adversely impacts renal cell carcinoma survival

Smoking adversely impacts renal cell carcinoma survival
For patients with clear cell renal cell carcinoma, smoking exposure adversely impacts cancer-specific survival and increases the risk of death from another cause, according to a study published in the March issue of The Journal of Urology.

(HealthDay)—For patients with clear cell renal cell carcinoma, smoking exposure adversely impacts cancer-specific survival and increases the risk of death from another cause, according to a study published in the March issue of The Journal of Urology.

Behfar Ehdaie, M.D., M.P.H., from the Memorial Sloan-Kettering Cancer Center in New York City, and colleagues examined the impact of exposure on cancer-specific survival in a cohort of 1,625 patients with clear cell . Data were collected from patients treated with surgery from 1995 through 2012 and the correlations between smoking status with advanced disease and cancer-specific survival were determined during a median follow-up of 4.5 years.

The researchers found that the prevalence of current, former, and never smoking was 16, 30, and 54 percent at diagnosis. A smoking history of 20 pack-years or greater was associated with a significantly increased risk of advanced disease on univariable analysis (odds ratio, 1.43). After adjustment for age and gender, the correlation was not independent. On multivariable competing risks analysis, pathological stage and Fuhrman grade adversely affected cancer-specific survival. On multivariable analysis, the correlation between smoking and cancer-specific survival did not achieve statistical significance (hazard ratio, 1.5; 95 percent confidence interval, 0.89 to 2.52), although there was a trend toward an adverse effect of smoking. The risk of death from another cause was significantly higher for current smokers than never smokers (hazard ratio, 1.93).

"Treatment plans to promote in survivorship programs are recommended for these patients," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Smoking cessation reduces risk of cataract extraction

Jan 07, 2014

(HealthDay)—Smoking cessation correlates with a reduction in the risk of cataract extraction, although the risk persists for more than 20 years, according to a study published online Jan. 2 in JAMA Ophthalmology.

Recommended for you

Video: Is that double mastectomy really necessary?

1 hour ago

When Angeline Vuong, 27,was diagnosed with cancer in one breast earlier this year, her first reaction was "A DOUBLE MASTECTOMY. NOW. " Turns out, she's far from alone: a recent JAMA study of 190,000 breast cancer cases in ...

User comments