Research could help improve early diagnosis of prostate cancer

Prostate cancer patients could get better diagnosis and treatment for the disease in the future thanks to a successful research project at the University of Essex.

Currently, is it difficult to distinguish between benign and aggressive malignant tumours, meaning some prostate cancer patients are unnecessarily "over-treated" which can lead to needless distress and anxiety.

Scientists in this field have been looking to find biomarkers to distinguish between the two types of tumours, and now prostate cancer experts at Essex have found an important link between the molecule known as BORIS and malignant tumours.

The research, published in the February issue of the journal Prostate, could lead the way for pathologists to have better tools for the early diagnosis of prostate cancer and for patients to get the most appropriate level of treatment for them.

The major three-year study involved the University-based Essex Biomedical Sciences Institute (EBSI) working with the Colchester Catalyst Charity and the Urology and Pathology Departments at Colchester Hospital University NHS Foundation Trust.

Leading the project at Essex was Professor Elena Klenova, who was part of the scientific team which first discovered BORIS in 2002 and its importance in prostate cancer research.

"Apart from playing an important role in the development of sperm in men, BORIS is not usually expressed in the body," explained Professor Klenova, "However, it does appear in malignant tumours, which is why it is seen as an important molecule in the development of cancer. It also can help distinguish between normal and cancerous cells".

Prostate cancer is the most common type of cancer in men. Around 37,000 UK men are diagnosed with the disease each year. Many develop very slowly, but in a small proportion of cases the cancer grows more quickly and spreads to other areas of the body, sometimes proving fatal.

The research was co- funded by the Colchester Catalyst Charity as part of its ongoing mission to improve the health care of people living in north-east Essex. However, the study's findings obviously have a wider impact generally for the treatment and the understanding of prostate cancer.

Professor Klenova's team at Essex, which included Zubair Cheema and Yukti Hari-Gupta, sponsored by Colchester Hospital University NHS Foundation Trust and the Colchester Catalyst Charity, respectively, looked at levels of BORIS in benign and malignant tumours and found that it was only present in malignant tumours, suggesting that the molecule could prove to be a useful biomarker for aggressive symptoms of the disease.

John Corr, consultant urological surgeon at Colchester Hospital University NHS Foundation Trust, said: "Collaborative work like this between a university and an acute hospital trust is a very under-utilised resource in the NHS, and I am very happy to be involved in it.

"This is a very exciting finding and will help in our daily fight against prostate cancer.

"It may more accurately identify those patients that need active treatment and aid in predicting long-term outcomes."

The scientists will now investigate the link between BORIS and malignant tumours further with a bigger study.

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

The fine line between breast cancer and normal tissues

11 hours ago

Up to 40 percent of patients undergoing breast cancer surgery require additional operations because surgeons may fail to remove all the cancerous tissue in the initial operation. However, researchers at Brigham ...

Pancreatic cancer risk not higher with diabetes Rx DPP-4i

12 hours ago

(HealthDay)—There is no increased short-term pancreatic cancer risk with dipeptidyl-peptidase-4 inhibitors (DPP-4i) compared to sulfonylureas (SU) and thiazolidinediones (TZD) for glycemic control, according ...

Good bowel cleansing is key for high-quality colonoscopy

15 hours ago

The success of a colonoscopy is closely linked to good bowel preparation, with poor bowel prep often resulting in missed precancerous lesions, according to new consensus guidelines released by the U.S. Multi-Society Task ...

New rules for anticancer vaccines

16 hours ago

Scientists have found a way to find the proverbial needle in the cancer antigen haystack, according to a report published in The Journal of Experimental Medicine.

User comments