Metformin use doesn't cut incidence of bladder cancer

February 11, 2014
Metformin use doesn't cut incidence of bladder cancer

(HealthDay)—For patients with type 2 diabetes, metformin use is not associated with a significantly reduced risk of bladder cancer, according to a study published online Feb. 4 in Diabetes Care.

Ronac Mamtani, M.D., from the University of Pennsylvania in Philadelphia, and colleagues conducted a involving 87,600 patients with in The Health Improvement Network database. The incidence of in new users of and sulfonylureas was examined. Metformin or sulfonylurea use was treated as a time-dependent variable. The authors hoped to address the time-related biases that may have affected previous studies relating to the effect of metformin on cancer risk.

The researchers identified 196 incident bladder cancers in the metformin cohort and 66 in the sulfonylurea cohort. The risk of bladder cancer was not significantly decreased in association with metformin use (hazard ratio, 0.81; 95 percent confidence interval [CI], 0.60 to 1.09). The correlation was not affected by sex (P for interaction = 0.20). There was also no reduction in bladder cancer risk with increased duration of metformin use relative to use of sulfonylureas (three to less than four years of use: 0.57 [95 percent CI, 0.25 to 1.34]; four to less than five years of use: 0.93 [95 percent CI, 0.30 to 2.85]; and five or more years of use: 1.18 [95 percent CI, 0.44 to 3.19]; P for trend = 0.26).

"Similar methods should be used to study other cancers that have previously been identified as potentially preventable with metformin," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: Lung cancer risk unaffected by metformin use in diabetes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Lung cancer risk unaffected by metformin use in diabetes

August 30, 2012

(HealthDay)—Patients with type 2 diabetes who take metformin do not have a reduced risk of lung cancer, in contrast to previous observational studies, according to a study published online Aug. 24 in Diabetes Care.

Sulfonylureas up cardio events versus metformin

November 7, 2012

(HealthDay)—Use of sulfonylureas for initial treatment of diabetes is associated with increased cardiovascular events and death compared with metformin, according to a study published in the Nov. 6 issue of the Annals of ...

Post-breast cancer, metformin has no effect on mortality

July 3, 2013

(HealthDay)—For older women with diabetes and breast cancer, there is no association between metformin use and all-cause or breast cancer-specific mortality, according to a study published online April 30 in Diabetes Care.

Metformin may increase risk of cognitive impairment

September 21, 2013

(HealthDay)—Metformin may increase the risk of cognitive impairment in patients with diabetes; however, calcium supplementation may attenuate this risk, according to research published online Sept. 5 in Diabetes Care.

Recommended for you

Combination therapy can prevent cytostatic resistance

November 26, 2015

Researchers at Karolinska Institutet have found a new way of preventing resistance to cytostatics used in the treatment of cancers such as medulloblastoma, the most common form of malignant brain tumour in children. The promising ...

Forecasting the path of breast cancer in a patient

November 23, 2015

USC researchers have developed a mathematical model to forecast metastatic breast cancer survival rates using techniques usually reserved for weather prediction, financial forecasting and surfing the Web.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.