MRI to offer advances in treatment for chronic kidney disease

Detailed structural and functional 'maps' of the human kidney made using advanced scanning technology are to be developed by scientists at The University of Nottingham.

The research, funded with £107,623 from the Dr Hadwen Trust, a non-animal biomedical research charity, aims to further our understanding of how the kidneys function, ultimately leading to better monitoring and treatment for .

It will be the first of its kind to use imaging to investigate the role which oxygen plays in keeping the human healthy.

The study is being led by Dr Sue Francis in the University's Sir Peter Mansfield Magnetic Resonance Centre in collaboration with Professor Chris McIntyre in the University's School of Medicine.

Dr Francis said: "Current tests for chronic can be very invasive and patients may need to return to the hospital on a number of occasions.

"The aim of this project is to produce a set of non-invasive measurements that we can produce in a single, one-hour scanning session that can assess the blood flow and oxygenation of the kidney and which could eventually be rolled out in a clinical setting to benefit patients."

The kidneys play a vital role in the human body, filtering waste products from the blood before converting them to urine. They also help to maintain blood pressure, regulate chemical levels in the body, keep bones healthy by producing a type of vitamin D and stimulate the production of .

However, health conditions such as diabetes and can affect how effectively the kidneys can work and can lead to chronic kidney disease, causing tiredness, water retention and weight loss and a loss of appetite.

The disease is currently diagnosed by a blood test which measures the GFR—glomerular filtration rate—which is the volume of blood which is filtered through the kidneys. In more serious kidney conditions, a renal biopsy may need to be performed, which involves removing a small sample of tissue from the kidney.

Dr Francis added: "Current methods can only offer a fairly crude picture of what is happening in the kidneys and how that is changing over time. For example, if one kidney is doing most of the work it can be difficult to tell and taking just a small sample of tissue from one area of the kidney may not be representative of the organ as a whole."

The research will instead use (MRI), powered by a 3 Tesla magnet, to scan the kidney and build up a detailed picture of perfusion in the kidney—the way in which blood is delivered to and flows through the organ. It will also measure the metabolic rate of oxygen—how oxygen is consumed within the kidney—which has not been done before using MR imaging.

The research will develop novel MRI techniques, and use these techniques in healthy volunteers to study the kidney's response to oxygen and CO2 changes to assess how the kidney behaves under stress which mimics diseased kidneys.

Next, the researchers will scan 20 patients with diabetic nephropathy (kidney disease caused by diabetes) in a bid to prove the effectiveness of their methods.

The scanning technique could be used to track the progression of a patient's disease and to monitor the effect and effectiveness of drugs being used to treat the condition.

add to favorites email to friend print save as pdf

Related Stories

Targeting certain kidney cells may help treat kidney failure

Jan 09, 2014

New research reveals that certain cells contribute to kidney function decline, making them attractive targets for treatments against kidney failure. The findings will appear in an upcoming issue of the Journal of the American So ...

Kidney patients may gain from less salt

Jan 31, 2014

(Medical Xpress)—Reducing salt consumption may help prolong the lives of patients with chronic kidney disease, a study from The University of Queensland study has found

Recommended for you

Dengue fever strikes models in Japan

1 hour ago

A worsening outbreak of dengue fever in Japan has claimed its first celebrities—two young models sent on assignment to the Tokyo park believed to be its source.

Japanese researchers develop 30-minute Ebola test

1 hour ago

Japanese researchers said Tuesday they had developed a new method to detect the presence of the Ebola virus in 30 minutes, with technology that could allow doctors to quickly diagnose infection.

Senegal monitors contacts of 1st Ebola patient

13 hours ago

Senegalese authorities on Monday were monitoring everyone who was in contact with a student infected with Ebola who crossed into the country, and who has lost three family members to the disease.

Cerebral palsy may be hereditary

19 hours ago

Cerebral palsy is a neurological developmental disorder which follows an injury to the immature brain before, during or after birth. The resulting condition affects the child's ability to move and in some ...

19 new dengue cases in Japan, linked to Tokyo park

Sep 01, 2014

Japan is urging local authorities to be on the lookout for further outbreaks of dengue fever, after confirming another 19 cases that were contracted at a popular local park in downtown Tokyo.

User comments