Probiotic treatment for vaginal thrush on the way

Scientists are testing vaginal pessaries containing 'good' probiotic bacteria for the treatment of vaginal thrush. Research published today in the Society for Applied Microbiology's Journal of Applied Microbiology shows that this approach is likely to be a viable alternative to using precious antimicrobial drugs.

The team, led by Dr M. Cristina Verdenelli at Università di Camerino, Italy, tested five strains of lactobacilli for their antimicrobial potential against the most common type of vaginal infections, Candida. Their in vitro experiments showed that the combination of two strains, Lactobacillus rhamnosus IMC 501 and Lactobacillus paracasei IMC 502, also known as SYNBIO, patented by Synbiotec Srl, had all the necessary characteristics.

Dr Verdenelli said "We've all heard of using natural yoghurt to manage vaginal thrush as an alternative to antimicrobial medicines, but we wanted to test whether the type of found in yoghurt could actually kill or restrict the growth of . The results in the lab have been very good and we have moved on to test our formulation in patients."

Dr Verdenelli's team were looking for two main characteristics of the bacteria: their ability to produce a substances that would likely kill the candida and their ability to grow on alongside the yeast infection. Of the five strains they tested, the SYNBIO formulation had the best overall characteristics, adhering well to human cells, growing alongside candida, and producing hydrogen peroxide to kill the yeast cells

Results from the human study, carried out at the Department of Obstetrics/Gynecology and Centre for Perinatal and Reproductive Medicine, Santa Maria della Misericorida, University Hospital of Perugia, in collaboration with Professor Gian Carlo Di Renzo, are pending.

With the increasing problem of antimicrobial resistance, it is vital to consider alternative methods of preventing and control infection and this study is a good example of scientists doing just that.

add to favorites email to friend print save as pdf

Related Stories

Coconut oil could combat tooth decay

Sep 03, 2012

Digested coconut oil is able to attack the bacteria that cause tooth decay. It is a natural antibiotic that could be incorporated into commercial dental care products, say scientists presenting their work at the Society for ...

Wash your mouth out with silver

Mar 08, 2012

Yeasts which cause hard-to-treat mouth infections are killed using silver nanoparticles in the laboratory, scientists have found. These yeast infections, caused by Candida albicans and Candida glabrata target the young, ol ...

Recommended for you

'Science' features advances in preterm birth

Aug 15, 2014

The Aug. 15 edition of the journal Science features a major article about the most important problem in obstetrics: preterm labor. The article, "Preterm labor: one syndrome, many causes," delivers a powerf ...

Treatment does not prevent pre-eclampsia, pregnancy loss

Aug 13, 2014

International research involving the University of Adelaide has shown an anti-blood clotting treatment that has been used for more than 20 years to prevent a range of serious pregnancy complications is not ...

User comments