Low rates of recurrence with 'no ink' as margin in breast CA

Low rates of recurrence with 'No ink' as margin in breast CA

(HealthDay)—Positive margins (ink on invasive carcinoma or ductal carcinoma in situ) are associated with increased risk of ipsilateral breast tumor recurrence (IBTR), according to consensus guidelines published online Feb. 10 in the Journal of Clinical Oncology.

Meena S. Moran, M.D., from the Yale University School of Medicine in New Haven, Conn., and colleagues conducted a systematic review of 33 studies involving 28,162 patients. The authors sought to reach a consensus regarding optimal margin width in breast-conserving surgery for and the risk of IBTR.

The researchers found that, compared with negative margins, positive margins (ink on or in situ) correlated with a two-fold increase in IBTR risk. Neither favorable biology, nor endocrine therapy, nor radiation boost mitigated the increased risk. Compared with no ink on tumor, more widely clear margins did not significantly decrease the rate of IBTR. No evidence was observed in support of more widely clear margins for reducing IBTR in young patients or for patients with unfavorable biology, lobular cancers, or cancers with an extensive intraductal component.

"The use of no ink on tumor as the standard for an adequate margin in invasive cancer in the era of multidisciplinary therapy is associated with low rates of IBTR and has the potential to decrease re-excision rates, improve cosmetic outcomes, and decrease health care costs," the authors write.

Several authors disclosed financial ties to the medical device industry.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Margin threshold for women with ductal carcinoma in situ

Mar 22, 2012

Negative surgical margins should be attained for ductal carcinoma in situ (DCIS) patients after breast-conserving surgery (BCS) regardless of radiotherapy, and surgeons should attempt to reach wide negative margins in their ...

Outcomes similar with partial, whole breast irradiation

Aug 24, 2012

(HealthDay)—Accelerated partial breast irradiation (APBI) yields five-year clinical outcomes and patterns of failure similar to those achieved with whole breast irradiation (WBI), with excellent three-year ...

Recommended for you

Researcher to cancer: 'Resistance will be futile'

5 hours ago

Turning the tables, Katherine Borden at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC) has evoked Star Trek's Borg in her fight against the disease. "Cancer cells rapidly ...

How does prostate cancer form?

7 hours ago

Prostate cancer affects more than 23,000 men this year in the USA however the individual genes that initiate prostate cancer formation are poorly understood. Finding an enzyme that regulates this process ...

Low risk of malignancy for small complex adnexal masses

14 hours ago

(HealthDay)—For older women with small complex adnexal masses, the overall risk of malignancy is low, according to a study published in the December issue of the American Journal of Obstetrics & Gynecology.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.