Worm infections in developing countries: Veterinary drugs improve the health of school children

School children are investigated for worm infection. Credit: Benjamin Speich / Swiss TPH

Hookworms and whipworms are detrimental to health. Children in many developing countries in particular are prone to regular infection via contaminated soil due to a lack of latrines and clean water. Whipworm eggs enter the body via the gastrointestinal tract and evolve over several devel-opment stages. To contain the health risks of worm infections, the WHO recommends annual de-worm treatment for children and at-risk groups (such as field hands and miners). However, the recommended standard treatment appears to have little effect against the widespread whipworm (Trichuris trichiura).

"We remembered that there was an effective deworming drug used in veterinary medicine," says head of the study Jennifer Keiser, from the Swiss Tropical and Public Health Institute. Following a preliminary study in the laboratory, her group tested the veterinary treatment 'Oxantel Pamoate' in combination with the standard treatment, Albendazole. The randomised double-blind trial with school with took place on the East African island of Pemba (Tanzania). After one treatment with this combination therapy, 31% of the children were free of worm infec-tions. The number of worm eggs in the children's stools decreased by 96% after one treatment.

Veterinary medicine for neglected worm infections

'Oxantel Pamoate' was developed in the 1970s to combat whipworm. Today, it is widely used in veterinary deworming drugs in combination with other substances. Studies in the 1970s showed that 'Oxantel Pamoate' is also a safe and effective way of tackling whipworm infections in humans. Yet, the drug was soon forgotten about and was never widely used for humans.

"Health experts in the field of worm infections have been discussing its use for some years now," says Jennifer Keiser: "The problem was the availability of the active ingredient as a single sub-stance." The manufacturers did not want to release the drug for human clini-cal trials and the is not commercially available.

Successful collaboration with pharmacists at the University of Basel

The solution was found during a collaboration with pharmacists at the University of Basel. Jörg Huwyler's laboratory in the Centre for Pharmaceutical Sciences succeeded in producing a tablet whose taste and colour were attractive to children. Thanks to this expertise, it was possible to de-velop the substance entirely independently of the pharmaceutical industry. Drug doses and delivery are currently being improved in further clinical trials. On the strength of the study, the WHO could extend its recommendation to include this substance in future. This would improve the health of millions of children worldwide.

More information: Oxantel Pamoate-Albendazole for Trichuris trichiura Infection. B. Speich, SM. Ame, SM. Ali, R. Alles, J. Huwyler, J. Hattendorf, J. Utzinger, M. Albonico , and J. Keiser, Ph.D. N Engl J Med 770;7, p. 610ff.

Provided by Swiss Tropical and Public Health Institute

not rated yet
add to favorites email to friend print save as pdf

Related Stories

Hookworm genome sequenced

Jan 19, 2014

Going barefoot in parts of Africa, Asia and South America contributes to hookworm infections, which afflict an estimated 700 million of the world's poor. The parasitic worm lives in the soil and enters the body through the ...

Mapping the world of worm infections

Aug 17, 2010

‘This Wormy World’, a series of maps showing the distribution and prevalence of worm infections across each country in Africa, launches today. The maps form the first part of the Global Atlas of Helminth ...

Tribendimidine shows promise against intestinal worms

Oct 15, 2008

Researchers have reported positive results from a safety and efficacy study pertaining to tribendimidine, a broad-based treatment for intestinal worm infections. The group's results demonstrate the success of the new drug ...

Recommended for you

Senegal monitors contacts of 1st Ebola patient

1 hour ago

Senegalese authorities on Monday were monitoring everyone who was in contact with a student infected with Ebola who crossed into the country, and who has lost three family members to the disease.

Cerebral palsy may be hereditary

7 hours ago

Cerebral palsy is a neurological developmental disorder which follows an injury to the immature brain before, during or after birth. The resulting condition affects the child's ability to move and in some ...

19 new dengue cases in Japan, linked to Tokyo park

13 hours ago

Japan is urging local authorities to be on the lookout for further outbreaks of dengue fever, after confirming another 19 cases that were contracted at a popular local park in downtown Tokyo.

User comments