Children with glomerular kidney disease more likely to have hypertension as adults

Men who as children had glomerular disease, a disorder of the portion of the kidney that filters blood and one that usually resolves with time, were more likely than men without childhood glomerular disease to have high blood pressure as an adult, according to a study in the March 19 issue of JAMA.

Glomerular disease was defined for this study as glomerulonephritis or nephrotic syndrome (both are kidney disorders). Most children who develop glomerular disease have a favorable prognosis with complete resolution of all signs and symptoms. Yet the long-term complications of resolved childhood glomerular disease are incompletely understood, according to background information in the article.

Asaf Vivante, M.D., of IDF Medical Corps, Tel-Hashomer, Israel, and colleagues conducted a study that included male military personnel in Israel, who had a baseline evaluation conducted prior to recruitment at age 17 years, during which the diagnosis of resolved childhood glomerular disease was determined. Participants were followed up until the diagnosis of hypertension (systolic >140 mm Hg or diastolic >90 mm Hg), retirement from service, or December 31, 2010, whichever came first.

The study included 38,144 career personnel, of whom 264 were diagnosed with a medical history of resolved childhood glomerular disease. During an average follow-up of 18 years, 2,856 participants developed hypertension; 13.6 percent of participants with a of resolved childhood glomerular disease and 7.4 percent of those without such history.

"In this study, resolved childhood glomerular disease was associated with subsequent risk of hypertension in a cohort of young healthy adult men," the authors write. They add that their results suggest that glomerular disease during childhood may initiate that manifests in adulthood, well before sufficient loss of excretory function can be measured with standard laboratory tests, such that the first manifestation may be adult .

More information: DOI: 10.1001/jama.2013.284310

add to favorites email to friend print save as pdf

Related Stories

HTN risk up for african-american live kidney donors

Nov 06, 2012

(HealthDay)—African-American live kidney donors have a significantly increased risk of hypertension compared with non-donors, according to a study published online Oct. 24 in the American Journal of Tr ...

Recommended for you

France to receive first Ebola patient

10 hours ago

France on Wednesday prepared to receive its first Ebola patient, as the World Bank warned the spiralling epidemic is threatening economic catastrophe in west Africa.

US scientist: Ebola unlikely to become airborne

11 hours ago

It is unlikely that Ebola would mutate to spread through the air, and the best way to make sure it doesn't is to stop the epidemic, a top U.S. government scientist told concerned lawmakers Wednesday.

User comments