Chronic pain research delves into the brain

by David Ellis

(Medical Xpress)—University of Adelaide researchers say new insights into how the human brain responds to chronic pain could eventually lead to improved treatments for patients.

Neuroplasticity is the term used to describe the brain's ability to change structurally and functionally with experience and use.

"Neuroplasticity underlies our learning and memory, making it vital during early childhood development and important for continuous learning throughout life," says Dr Ann-Maree Vallence, a Postdoctoral Fellow in the University of Adelaide's Robinson Institute.

"The mechanisms responsible for the development of chronic pain are poorly understood. While most research focuses on changes in the , this research investigates the role of in the development of chronic pain."

In Australia, approximately 20% of adults suffer moderate to severe chronic pain.

Dr Vallence, who is based in the Robinson Institute's Neuromotor Plasticity and Development Group, has conducted a study on patients with chronic tension-type headache (CTTH), a common chronic pain disorder. CTTH is characterised by a dull, constant feeling of pressure or tightening that usually affects both sides of the head, occurring for 15 days or more per month. Other symptoms include poor sleep, irritability, disturbed memory and concentration, and depression and anxiety.

"People living with chronic headache and other forms of chronic pain may experience reduced quality of life, as the pain often prevents them from working, amongst other things. It is therefore imperative that we understand the causes of chronic pain, not just attempt to treat the symptoms with medication," Dr Vallence says.

In this study, participants undertook a motor training task consisting of moving their thumb as quickly as possible in a specific direction. The change in performance (or learning) on the task was tracked by recording how quickly subjects moved their thumb. A non-invasive brain stimulation technique was also used to obtain a measure of the participants' .

"Typically, when individuals undertake a motor training task such as this, their performance improves over time and this is linked with a neuroplastic change in the brain," Dr Vallence says. "The people with no history of chronic pain got better at the task with training, and we observed an associated neuroplastic change in their brains. However, our chronic headache patients did not get better at the task and there were no associated changes in the brain, suggesting impaired neuroplasticity.

"These results provide a novel and important insight into the cause of chronic pain, and could eventually help in the development of a more targeted treatment for CTTH and other conditions," she says.

add to favorites email to friend print save as pdf

Related Stories

Can meditation decrease chronic pain?

Oct 23, 2013

A randomized controlled study published in the current issue of Psychotherapy and Psychosomatics has investigated the role of a special form of meditation (mindfulness) in Chronic pain.

Recommended for you

New ALS associated gene identified using innovative strategy

Oct 22, 2014

Using an innovative exome sequencing strategy, a team of international scientists led by John Landers, PhD, at the University of Massachusetts Medical School has shown that TUBA4A, the gene encoding the Tubulin Alpha 4A protein, ...

Can bariatric surgery lead to severe headache?

Oct 22, 2014

Bariatric surgery may be a risk factor for a condition that causes severe headaches, according to a study published in the October 22, 2014, online issue of Neurology, the medical journal of the American Academy of Neurol ...

Bipolar disorder discovery at the nano level

Oct 22, 2014

A nano-sized discovery by Northwestern Medicine scientists helps explain how bipolar disorder affects the brain and could one day lead to new drug therapies to treat the mental illness.

User comments