Hepatic decompensation higher with HIV, HCV co-infection

Hepatic decompensation higher with HIV, HCV co-infection

(HealthDay)—Patients co-infected with HIV and hepatitis C virus (HCV) have higher rates of hepatic decompensation than those with HCV monoinfection, according to a study published in the March 18 issue of the Annals of Internal Medicine.

Vincent Lo Re III, M.D., from the University of Pennsylvania and the Philadelphia VA Medical Center, and colleagues conducted a to compare the incidence of hepatic decompensation between 4,280 antiretroviral-treated patients co-infected with HIV and HCV and 6,079 HCV-monoinfected patients. All patients were HCV treatment-naive and had detectable HCV RNA.

The researchers found that, at 10 years, the incidence of hepatic decompensation was 7.4 percent among co-infected patients and 4.8 percent among monoinfected patients (P < 0.001). Co-infected patients had a higher rate of hepatic decompensation than HCV-monoinfected patients (hazard ratio [HR] accounting for competing risks, 1.56). The rate of decompensation was also higher in co-infected patients who maintained HIV RNA levels <1,000 copies/mL compared with HCV-monoinfected patients (HR, 1.44). Among co-infected patients, higher rates of decompensation were associated with baseline advanced hepatic fibrosis (HR, 5.45 with FIB-4 score >3.25); baseline hemoglobin level <100g/L (HR, 2.24); diabetes mellitus (HR, 1.88); and nonblack race (HR, 2.12).

"Despite receiving antiretroviral therapy, patients co-infected with HIV and HCV had higher rates of hepatic decompensation than HCV-monoinfected patients," the authors write.

More information: Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Study quantifies prevalence of chronic HCV infection

Mar 04, 2014

(HealthDay)—The prevalence of hepatitis C virus (HCV) infection is about 1 percent, with 2.7 million U.S. residents estimated as having chronic HCV infection, according to a study published in the March ...

HIV-HCV coinfection speeds HCV-related liver fibrosis

Feb 27, 2013

(HealthDay)—Individuals who are coinfected with HIV and hepatitis C virus (HCV) exhibit liver fibrosis similar to that of individuals without HIV who are nearly 10 years older, according to research published ...

Better long-term outcomes with low hep C viral load

Mar 25, 2013

(HealthDay)—In patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC), low HCV viral load predicts better long-term surgical outcomes, regardless of the serologic eradication of HCV, ...

Recommended for you

Ebola reveals shortcomings of African solidarity

16 hours ago

As Africa's leaders meet in Ethiopia to discuss the Ebola crisis, expectations of firm action will be tempered by criticism over the continent's poor record in the early stages of the epidemic.

Second bird flu case confirmed in Canada

Jan 30, 2015

The husband of a Canadian who was diagnosed earlier this week with bird flu after returning from a trip to China has also tested positive for the virus, health officials said Friday.

What exactly is coronavirus?

Jan 30, 2015

The conflicts in Syria and Iraq are straining public health systems and public health efforts meant to prevent and detect the spread of infectious diseases. This is generating a "perfect storm" of conditions for outbreaks. Among the infections raising concern is Middle East Respiratory Syndrome, caused by a type of coronavirus, which emerged in 2012. ...

Scientists find Ebola virus is mutating

Jan 30, 2015

(Medical Xpress)—Researchers working at Institut Pasteur in France have found that the Ebola virus is mutating "a lot" causing concern in the African countries where the virus has killed over eight thous ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.