Hepatic decompensation higher with HIV, HCV co-infection

Hepatic decompensation higher with HIV, HCV co-infection

(HealthDay)—Patients co-infected with HIV and hepatitis C virus (HCV) have higher rates of hepatic decompensation than those with HCV monoinfection, according to a study published in the March 18 issue of the Annals of Internal Medicine.

Vincent Lo Re III, M.D., from the University of Pennsylvania and the Philadelphia VA Medical Center, and colleagues conducted a to compare the incidence of hepatic decompensation between 4,280 antiretroviral-treated patients co-infected with HIV and HCV and 6,079 HCV-monoinfected patients. All patients were HCV treatment-naive and had detectable HCV RNA.

The researchers found that, at 10 years, the incidence of hepatic decompensation was 7.4 percent among co-infected patients and 4.8 percent among monoinfected patients (P < 0.001). Co-infected patients had a higher rate of hepatic decompensation than HCV-monoinfected patients (hazard ratio [HR] accounting for competing risks, 1.56). The rate of decompensation was also higher in co-infected patients who maintained HIV RNA levels <1,000 copies/mL compared with HCV-monoinfected patients (HR, 1.44). Among co-infected patients, higher rates of decompensation were associated with baseline advanced hepatic fibrosis (HR, 5.45 with FIB-4 score >3.25); baseline hemoglobin level <100g/L (HR, 2.24); diabetes mellitus (HR, 1.88); and nonblack race (HR, 2.12).

"Despite receiving antiretroviral therapy, patients co-infected with HIV and HCV had higher rates of hepatic decompensation than HCV-monoinfected patients," the authors write.

More information: Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Study quantifies prevalence of chronic HCV infection

Mar 04, 2014

(HealthDay)—The prevalence of hepatitis C virus (HCV) infection is about 1 percent, with 2.7 million U.S. residents estimated as having chronic HCV infection, according to a study published in the March ...

HIV-HCV coinfection speeds HCV-related liver fibrosis

Feb 27, 2013

(HealthDay)—Individuals who are coinfected with HIV and hepatitis C virus (HCV) exhibit liver fibrosis similar to that of individuals without HIV who are nearly 10 years older, according to research published ...

Better long-term outcomes with low hep C viral load

Mar 25, 2013

(HealthDay)—In patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC), low HCV viral load predicts better long-term surgical outcomes, regardless of the serologic eradication of HCV, ...

Recommended for you

Dallas hospital confirms first Ebola case in US

32 minutes ago

A patient at a Dallas hospital has tested positive for Ebola, the first case of the disease to be diagnosed in the United States, federal health officials announced Tuesday.

First case of Ebola diagnosed in US

1 hour ago

The United States has diagnosed its first case of the deadly Ebola virus in a man who became infected in Liberia and traveled to Texas, US health officials said Tuesday.

Study finds acupuncture does not improve chronic knee pain

2 hours ago

Among patients older than 50 years with moderate to severe chronic knee pain, neither laser nor needle acupuncture provided greater benefit on pain or function compared to sham laser acupuncture, according to a study in the ...

Ebola outbreak nears end in Nigeria

3 hours ago

The Ebola outbreak in Nigeria is almost over, US health officials said Tuesday, in a rare sign of authorities turning the tide on the highly contagious disease that has killed more than 3,000 in West Africa.

User comments