ISICEM: Albumin does not improve survival in sepsis

ISICEM: albumin does not improve survival in sepsis

(HealthDay)—For patients with severe sepsis in intensive care units, the use of albumin replacement in addition to crystalloid solution does not improve survival, according to a study published online March 18 in the New England Journal of Medicine. This research was published to coincide with the International Symposium on Intensive Care and Emergency Medicine, held from March 18 to 21 in Brussels.

Pietro Caironi, M.D., Ph.D., from the Università degli Studi di Milano, and colleagues randomized 1,818 patients with in 100 units to receive 20 percent albumin and crystalloid solution or crystalloid solution alone.

The researchers found that, compared with those in the crystalloid group, patients in the albumin group had a higher mean arterial pressure (P = 0.03) and lower net fluid balance (P < 0.001) during the first seven days. There was no significant between-group difference in the total daily amount of administered fluid (P = 0.10). At 28 days, 31.8 percent of the albumin group and 32.0 percent of the crystalloid group had died (relative risk in albumin group, 1.00; P = 0.94). Mortality at 90 days was 41.1 and 43.6 percent, respectively (relative risk, 0.94; P = 0.29).

"In with severe sepsis, albumin replacement in addition to crystalloids, as compared with crystalloids alone, did not improve the rate of survival at 28 and 90 days," the authors write.

The study was funded by the Italian Medicines Agency.

More information: Abstract
Full Text
More Information

add to favorites email to friend print save as pdf

Related Stories

Albumin improves bacterial peritonitis outcomes

Feb 07, 2013

(HealthDay)—For patients with spontaneous bacterial peritonitis (SBP), albumin infusion is associated with reduced renal impairment and decreased mortality, according to research published in the February ...

Ringer's acetate better for patients with severe sepsis

Jun 28, 2012

(HealthDay) -- Fluid resuscitation with hydroxyethyl starch (HES) 130/0.4 for patients with severe sepsis leads to an increased risk of death at day 90 and an increased likelihood of requiring renal-replacement ...

Recommended for you

Restrictions lifted at British bird flu farm

19 hours ago

Britain on Sunday lifted all restrictions at a duck farm in northern England after last month's outbreak of H5N8 bird flu, the same strain seen in recent cases across Europe.

Recorded Ebola deaths top 7,000

Dec 20, 2014

The worst Ebola outbreak on record has now killed more than 7,000 people, with many of the latest deaths reported in Sierra Leone, the World Health Organization said as United Nations Secretary-General Ban ...

Liberia holds Senate vote amid Ebola fears (Update)

Dec 20, 2014

Health workers manned polling stations across Liberia on Saturday as voters cast their ballots in a twice-delayed Senate election that has been criticized for its potential to spread the deadly Ebola disease.

Evidence-based recs issued for systemic care in psoriasis

Dec 19, 2014

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.