Targeting monocyte function to reverse atherosclerosis

Targeting monocyte function to reverse atherosclerosis
CLA inhibits polarisation of monocytes to pro-migratory phenotype. Confocal microscopy of human peripheral blood monocytes treated with CLA isomers, vehicle (VC), control lipids (OA) and positive control (TROG). CLA inhibts migratory response of HPBMCs.

(Medical Xpress)—The Belton group recently published findings describing a novel mechanism through which a dietary fatty acid alters monocyte function inducing regression of pre-established atherosclerosis.

Atherosclerosis, the underlying cause of heart disease and stroke, is a complex progressive disease involving multiple genetic and environmental factors.

One of the contributing factors to the development of the is the continual recruitment of circulating pro-inflammatory monocytes to the damaged blood vessel and their subsequent migration through the activated endothelial where they rapidly differentiate into macrophages

The recruitment of monocytes is a highly orchestrated process. Transmembrane proteins called integrins play a central role in this by mediating rolling and adhesion of leukocytes essentially causing them to adhere to the developing plaque.

The Belton group have previously shown in a murine model of that conjugated linoleic acid (CLA), alters monocyte/macrophage function causing regression of the disease.

Dr Orina Belton said, "We are trying to define the mechanisms through which CLA mediates its atheroprotective effect so as to identify novel pathways that limit or ultimately reverse atherosclerosis.

In this study, we have been able to clearly demonstrate that CLA targets integrin gene expression so as to suppress the ability of monocytes to adhere to . We also show that CLA modulates monocytes toward an anti-inflammatory phenoype resulting in impaired monocyte migration "

The data presented by the Belton group describe a novel functional role for CLA in the regulation of monocyte adhesion, polarisation, and migration.

More information: "Conjugated Linoleic Acid Targets b2 Integrin Expression To Suppress Monocyte Adhesion." de Gaetano, M; Dempsey E et al. Journal of Immunology, 2013, 191: 4326–4336. 

add to favorites email to friend print save as pdf

Related Stories

Monocyte migrations

Feb 19, 2013

LMU researchers led by Christian Weber have, for the first time, elucidated how cells that promote the development of atherosclerosis find their way to the blood vessel wall, where they stimulate the formation of obstructive ...

The Janus-like nature of JAM-A

Sep 30, 2013

A new study by Ludwig-Maximilians-Universitaet (LMU) in Munich researchers led by Christian Weber sheds light on the role of the adhesion molecule JAM-A in the recruitment of immune cells to the inner layer ...

Recommended for you

Profilin can induce severe food-allergic reactions

14 hours ago

(HealthDay)—Profilins are complete food allergens in food-allergic patient populations that are exposed to high levels of grass pollen, according to a study published in the December issue of Allergy.

Structured education program beneficial for anaphylaxis

Nov 21, 2014

(HealthDay)—A structured education intervention improves knowledge and emergency management for patients at risk for anaphylaxis and their caregivers, according to a study published online Nov. 19 in Allergy.

Every step you take: STING pathway key to tumor immunity

Nov 20, 2014

A recently discovered protein complex known as STING plays a crucial role in detecting the presence of tumor cells and promoting an aggressive anti-tumor response by the body's innate immune system, according to two separate ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.