Pre-op pregabalin best for pain in spinal surgery

Pre-op pregabalin best for pain in spinal surgery

(HealthDay)—Preoperative pregabalin is superior to either gabapentin or placebo for the relief of pain in patients undergoing lumbar discectomy, according to a study published in the March 15 issue of Spine.

Gurjeet Khurana, M.D., from HIHT University in Dehradun, India, and colleagues compared 300 mg of (Group A), 75 mg of pregabalin (Group B), or placebo (Group C) in 90 patients (aged 18 to 75 years) undergoing spinal surgery. One dose was given one hour before surgery and at eight hour intervals for seven days afterwards. Postoperative static and dynamic pain and functional outcome were assessed using a visual analogue scale, the Prolo functional and economic score, and the Oswestry Disability Index score, both preoperatively and three months postoperatively.

The researchers found that subjects receiving pregabalin showed consistently reduced static and dynamic pain intensity and also required a lesser amount of rescue drug throughout the . At all time intervals there was a statistically significant difference (P < 0.05) in the Prolo score and the Oswestry Disability Index score between group B and group C. There was a significant difference in the functional outcome between group A and group B at three months.

"Preoperative pregabalin administration is associated with less pain intensity and improved functional outcomes three months after lumbar discectomy followed by gabapentin and then ," the authors write.

More information: Full Text

add to favorites email to friend print save as pdf

Related Stories

Pre-op depression skews satisfaction after lumbar sx

Jun 04, 2013

(HealthDay)—Preoperative depression influences self-reported patient satisfaction after revision lumbar surgery, independent of the surgery's effectiveness, according to a study published in the May issue ...

IV acetaminophen eases post-spinal op pain for children

Sep 23, 2012

(HealthDay)—Children and adolescents given intravenously (IV)-administered acetaminophen after major spine surgery have significantly less postoperative pain, compared with those given placebo, but administration ...

Wait time to lumbar discectomy linked to post-op pain

Jan 21, 2014

(HealthDay)—The likelihood of experiencing worse pain at six months post-surgery is increased with a waiting time of 12 weeks or more for elective surgical lumbar discectomy (ESLD), according to a study ...

Recommended for you

Breakthrough could prevent hip implant replacement

20 hours ago

Hip implants rely on the normal functioning of bone cells to achieve fixation of the implant with the bone. However, small metal particles released from hip implants, due to friction between the moving surfaces, ...

Ultrasound can accurately diagnose carpal tunnel

Sep 30, 2014

(HealthDay)—Ultrasound can accurately confirm the diagnosis of carpal tunnel syndrome, according to a study published in the Sept. 3 issue of The Journal of Bone & Joint Surgery.

User comments