Single-patient trials determine statin tolerability

March 4, 2014
Single-patient trials determine statin tolerability

(HealthDay)—In patients with statin-related myalgia, single-patient randomized trials of statin and placebo can determine whether the myalgia is actually due to the statin, according to a small study published in the March 4 issue of the Annals of Internal Medicine.

Tisha R. Joy, M.D., from Western University in London, Canada, and colleagues conducted n-of-1 trials in eight patients with statin-related myalgia. Patients were randomly assigned to statin or placebo for up to three weeks, with three-week washout intervals.

The researchers found that for each patient there were no significant differences between statin or placebo in terms of visual analog scale myalgia score, symptom-specific visual analog scale score, pain interference score, and pain severity score. Five patients resumed , reducing their low-density lipoprotein cholesterol after a median of 10 months of follow-up.

"In selected patients with a history of statin-related myalgia whose symptoms are difficult to evaluate, n-of-1 trials may be a useful method for determining statin tolerability," Joy and colleagues conclude.

Explore further: Most statin-intolerant patients can eventually tolerate statins

More information: Full Text (subscription or payment may be required)

Related Stories

Cataract risk up for statin users with type 2 diabetes

August 13, 2012

(HealthDay) -- Statin use, which is substantially higher in patients with type 2 diabetes, correlates with an increased risk of age-related (AR) cataracts, according to a study published in the August issue of Optometry and ...

Recommended for you

Optimism may reduce risk of dying prematurely among women

December 7, 2016

Having an optimistic outlook on life—a general expectation that good things will happen—may help people live longer, according to a new study from Harvard T.H. Chan School of Public Health. The study found that women ...

New discovery at heart of healthy cereals

December 6, 2016

A new discovery at the University of Queensland could help reduce heart disease and boost nutrition security – the access to balanced nourishment - globally.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.