In STEMI, hyperglycemia tied to larger myocardial area-at-risk

In STEMI, hyperglycemia tied to larger myocardial area-at-risk

(HealthDay)—For patients with ST-segment elevation myocardial infarction (STEMI), hyperglycemia is associated with larger area-at-risk and infarct size, and the effect of exenatide treatment is independent of glucose levels, according to a study published online Feb. 28 in Diabetes.

Jacob Lønborg, M.D., Ph.D., from Copenhagen University Hospital in Denmark, and colleagues examined the correlation between and infarct size, myocardial salvage, and area-at-risk in a cohort of 210 patients with STEMI. Participants were randomized to receive intravenous exenatide or placebo before , and the interaction between exenatide and hyperglycemia was assessed.

The researchers found that larger area-at-risk and infarct size were seen for patients with hyperglycemia versus those with normoglycemia, but no difference was seen between the groups in the salvage index and infarct size after adjustment for area-at-risk. For patients with hyperglycemia and those with normoglycemia, exenatide treatment correlated with increased salvage index.

"Thus, we conclude that the association between hyperglycemia upon admission and infarct size in STEMI patients is a consequence of a larger myocardial area-at-risk but not on a reduction in myocardial salvage. Also, cardioprotection by exenatide treatment is independent of admission ," the authors write. "Hyperglycemia does not influence the effect of the reperfusion treatment but rather represents a surrogate marker for the severity of myocardium at risk and injury."

One author disclosed being a shareholder in CellAegis; several authors disclosed financial ties to Eli Lilly.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

White blood cell count predicts infarct size in STEMI

date Dec 19, 2013

(HealthDay)—For patients with anterior wall ST-segment elevated myocardial infarction (STEMI), elevated white blood cell count (WBCc) on presentation is associated with increased infarct size, according ...

AMI up with stress-induced hyperglycemia after hip fx

date Jul 15, 2013

(HealthDay)—For patients after hip fracture, stress-induced hyperglycemia is associated with an increased risk of acute myocardial infarction (AMI), according to a study published online July 11 in Diabetes Ca ...

Results of the CHILL-MI trial presented

date Oct 31, 2013

A clinical trial shows that rapidly cooling patients who have suffered ST-elevation myocardial infarction (STEMI, the most serious form of a heart attack) prior to restoring blood flow is safe and feasible. The findings of ...

Recommended for you

Faster heart rate linked to diabetes risk

date May 22, 2015

An association between resting heart rate and diabetes suggests that heart rate measures could identify individuals with a higher future risk of diabetes, according to an international team of researchers.

EBV co-infection may boost malaria mortality in childhood

date May 21, 2015

Many people who live in sub-Saharan Africa develop a natural immunity to malaria, through repeated exposure to Plasmodium parasites. Even so, the disease kills close to half a million children per year, according ...

Three important things you didn't know about diabetes

date May 21, 2015

When we think of diabetes, we tend to think of rich people with poor lifestyles. A chronic disease linked with obesity, heart disease and worse outcomes for some infectious diseases, diabetes tends to be ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.