AACR: ICMgp100 tolerated, active in advanced melanoma

April 9, 2014
AACR: ICMgp100 tolerated, active in advanced melanoma

(HealthDay)—An affinity-enhanced T cell receptor specific for the human leukocyte antigen-A2 restricted melanoma gp 100 peptide fused to an anti-CD3 antibody fragment, IMCgp100, seems promising for advanced melanoma, according to a study presented at the annual meeting of the American Association for Cancer Research, held from April 5 to 9 in San Diego.

Mark Middleton, M.D., Ph.D., from the NIHR Biomedical Research Centre in Oxford, U.K., and colleagues conducted a phase I study to determine the maximum tolerated dose and toxicity of ICMgp100. Thirty-one patients with were enrolled in eight cohorts and received doses of 5 to 900 ng/kg ICMgp100.

The researchers found that two of four patients developed grade 3 hypotension at a dose of 900 ng/kg, and consequently the maximum tolerated dose was established as 600 ng/kg. Transient grade 3 pruritic rash and grade 2 pyrexia were common toxicities. There was evidence of profound lymphocyte trafficking to the skin, as observed in immunohistochemical analysis of skin biopsies, and this was accompanied by chemokine/cytokine release. To date, four partial responses and multiple lesser responses have been documented, with one of the partial responses occurring after a single dose. Two partial responses persisted beyond more than nine months of continued treatment.

"The drug is well tolerated in advanced , and we have seen clinical responses in some of them," Middleton said in a statement.

The study was funded by Immunocore.

More information: Press Release
More Information

Related Stories

Chemo combination promising for multiple myeloma

May 2, 2012

(HealthDay) -- For patients with relapsed or refractory multiple myeloma, combination treatment with elotuzumab, lenalidomide, and low-dose dexamethasone is generally well tolerated, with encouraging response rates, according ...

ASCO: Dabrafenib/Trametinib active in metastatic melanoma

May 17, 2012

(HealthDay) -- For patients with V600 BRAF-mutant solid tumors, treatment with the oral BRAF inhibitor dabrafenib and the oral MEK 1/2 inhibitor trametinib is tolerated and has clinical activity in BRAF inhibitor-naive metastatic ...

AACR: LY2835219 promising for metastatic breast cancer

April 7, 2014

(HealthDay)—The novel cell cycle inhibitor selective for the cyclin-dependent kinases CDK4 and CDK6 (CDK4/6), LY2835219, shows promise for metastatic breast cancer, according to a study presented at the annual meeting of ...

Recommended for you

Study reveals new insight into DNA repair

August 3, 2015

DNA double-strand breaks (DSBs) are the worst possible form of genetic malfunction that can cause cancer and resistance to therapy. New information published this week reveals more about why this occurs and how these breaks ...

Strange circular DNA may offer new way to detect cancers

July 30, 2015

Strange rings of DNA that exist outside chromosomes are distinct to the cell types that mistakenly produced them, researchers have discovered. The finding raises the tantalizing possibility that the rings could be used as ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.