Researchers identify a gene that causes excessive androgen production in polycystic ovary syndrome

by Frances Dumenci

Researchers from Penn State College of Medicine and Virginia Commonwealth University School of Medicine have found that a specific protein is increased in theca cells, the source of excess male sex hormones, or androgens, that characterizes polycystic ovary syndrome (PCOS). The results of the study will be published in an upcoming issue of the Proceedings of the National Academy of Sciences (PNAS) as the journal cover article. The paper will be available in this week's online Early Edition.

PCOS is a common disease affecting 7 percent of reproductive-aged women worldwide. Symptoms of PCOS include increased male sex hormone levels, which cause hirsutism and acne; infertility due to the failure to ovulate; and enlarged ovaries with follicle cysts. In addition, obesity and diabetes are often associated with PCOS.

"There is a consensus that theca of are the primary source of excess androgens that characterizes PCOS," said Jan M. McAllister, Ph.D., lead author of the study and professor of pathology and obstetrics and gynecology at Penn State College of Medicine.

Studies conducted over the past decade have built a convincing argument that genetic factors contribute to PCOS. However, despite advances in genetic technologies, few if any PCOS susceptibility genes have been validated. The current study found that an alternative product of the DENND1A gene, DENND1A.V2, is increased in PCOS theca cells.

McAllister noted, "Prior to our studies, there was no pathophysiological link between DENND1A to reproduction or ovarian function. Our observations suggest that DENND1A is involved in a signaling cascade that subsequently results in increased androgen production."

The study showed that raising DENND1A.V2 in normal theca cells increases the expression of genes that lead to elevated androgen production. It also found that silencing DENND1A.V2 in PCOS theca cells reverts them to a normal phenotype.

"Our findings establish that increased DENND1A.V2 expression is sufficient to promote a PCOS phenotype in human theca cells," said Jerome F. Strauss, M.D., Ph.D., senior author of the study and dean of the VCU School of Medicine. "This information can inform development of diagnostic tests for PCOS based on measurements of DENND1A.V2, and may one day lead to novel therapeutic interventions, including drugs or antibodies that neutralize the action of DENND1A.V2."

More information: Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype, www.pnas.org/cgi/doi/10.1073/pnas.1400574111

add to favorites email to friend print save as pdf

Related Stories

Women with PCOS have family heart disease link

Oct 05, 2011

A new study from the University of Adelaide shows the parents of women with polycystic ovary syndrome (PCOS) are more likely to have some form of cardiovascular disease.

New diagnostics for ovarian syndrome

Dec 05, 2013

(Medical Xpress)—Having multiple ovarian follicles is the leading cause of infertility in America, with wider implications for cancer, cardiovascular disease, metabolic syndromes, hormonal imbalance and ...

Recommended for you

Lebanon reports first suspected case of Ebola

1 minute ago

A Lebanese man who arrived from West Africa is suspected of having Ebola and was quarantined on Thursday in a Beirut hospital, the first such suspected case in the country, Lebanon's health minister said.

New, faster therapeutic hypothermia techniques

16 minutes ago

Rapid lowering of body temperature following an acute myocardial infarction (MI) can be an effective therapeutic strategy to minimize damage to the heart muscle caused by the loss and restoration of blood ...

Sri Lanka celebrates two years without malaria

4 hours ago

Sri Lanka has not reported a local case of malaria since October 2012, according to the Sri Lankan Anti-Malarial Campaign. If it can remain malaria-free for one more year, the country will be eligible to apply to the World ...

User comments