Modafinil doesn't improve NSCLC-related fatigue

Modafinil doesn't improve NSCLC-related fatigue

(HealthDay)—The central nervous system stimulant modafinil is not effective in treating non-small-cell lung cancer-related fatigue, according to a study published online April 28 in the Journal of Clinical Oncology.

Anna Spathis, M.B., B.Chir.,from Cambridge University Hospitals National Health Service Foundation Trust in the United Kingdom, and colleagues randomly assigned adults with advanced non-small-cell lung cancer, who were not treated with chemotherapy or radiotherapy within the last four weeks, to receive either daily (75 patients) or matched placebo (85 patients). Questionnaires were completed at baseline and day 28.

The researchers found that, from baseline to day 28, Functional Assessment of Chronic Illness Therapy-Fatigue scores improved in both groups (mean score change: modafinil, 5.29; placebo, 5.09), with no difference between treatment groups (mean score change difference: 0.20; 95 percent confidence interval, −3.56 to 3.97). Secondary outcomes of patient-reported measures of depression, daytime sleepiness, and quality of life were not different between treatment groups. Forty-seven and 23 percent of the modafinil and placebo groups, respectively, stated that the intervention was not helpful.

"Modafinil had no effect on cancer-related fatigue and should not be prescribed outside a clinical trial setting," the authors write. "Its use was associated with a clinically significant placebo effect."

Matched modafinil and capsules were provided by Bilcare Global Clinical Supplies Europe.

More information: Abstract
Full Text

Related Stories

Dexamethasone beats placebo for cancer-related fatigue

date Aug 01, 2013

(HealthDay)—For patients with advanced cancer, dexamethasone is better than placebo for reducing cancer-related fatigue (CRF), according to a study published online July 29 in the Journal of Clinical On ...

L-carnitine does not reduce cancer-related fatigue

date Sep 18, 2012

(HealthDay)—Patients with invasive malignancies who take L-carnitine supplements do not experience a reduction in fatigue, pain, or depression, according to research published online Sept. 17 in the Journal of ...

Recommended for you

Vortex device makes for better cancer treatments

date 17 hours ago

A South Australian invention, responsible for unboiling an egg, has been used to produce a four-fold increase in efficacy of carboplatin, a commonly used drug for ovarian, lung and other cancer. ...

Using healthy skin to identify cancer's origins

date May 21, 2015

Normal skin contains an unexpectedly high number of cancer-associated mutations, according to a study published in Science. The findings illuminate the first steps cells take towards becoming a cancer and de ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.