Serum marker predicts cardiovascular events in diabetes

Serum marker predicts cardiovascular events in diabetes

(HealthDay)—Elevated levels of polyclonal serum immunoglobulin combined free light chains (cFLCs) may indicate adverse cardiovascular disease (CVD) outcomes in patients with type 2 diabetes, according to research published online April 17 in Diabetes Care.

Srikanth Bellary, M.B.B.S., of Aston University in Birmingham, U.K., and colleagues conducted a of 352 South Asian patients with type 2 diabetes to assess the association between cFLCs and cardiovascular disease events.

The researchers found that, among patients with type 2 diabetes who had CVD events during two years of follow-up, cFLC levels were elevated in 8 percent (50.7 versus 42.8 mg/L; P = 0.004). According to , elevated cFLC level (greater than 57.2 mg/L) was associated with adverse CVD outcomes (odds ratio, 3.3; 95 percent confidence interval, 1.3 to 8.2; P = 0.012). This association remained significant after adjustment for age, albumin-to-creatinine ratio, diabetes duration, or treatment.

"cFLC elevation is a novel marker for CVD outcomes in type 2 diabetes that warrants further investigation," the authors write.

The United Kingdom Asian Diabetes Study and several study authors received funding from pharmaceutical companies.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Genetic predisposition to diabetes ups risk of CVD

Oct 23, 2012

(HealthDay)—For patients with type 2 diabetes (T2D), having a genetic predisposition towards the disease is associated with an increased risk of cardiovascular disease (CVD), according to a study published ...

Interarm BP difference may up cardiac risk in diabetes

Apr 03, 2014

(HealthDay)—Interarm differences in systolic blood pressure (BP) in patients with diabetes may be associated with an increased risk of cardiovascular morbidity and mortality, according to research published ...

Omega-3 fatty acids, xanthophylls don't cut CVD risk

Mar 21, 2014

(HealthDay)—Dietary supplementation with ω-3 polyunsaturated fatty acids or macular xanthophylls do not seem to reduce the risk of cardiovascular disease (CVD) in older adults with age-related macular ...

Recommended for you

Shift work linked to heightened risk of type 2 diabetes

Jul 24, 2014

Shift work is linked to a heightened risk of developing type 2 diabetes, with the risk seemingly greatest among men and those working rotating shift patterns, indicates an analysis of the available evidence published online ...

Rosemary and oregano contain diabetes-fighting compounds

Jul 23, 2014

The popular culinary herbs oregano and rosemary are packed with healthful compounds, and now lab tests show they could work in much the same way as prescription anti-diabetic medication, scientists report. In their new study ...

User comments